| Player | POS | Status | |
|---|---|---|---|
| X. Chapman | DL | Questionable - Undisclosed ( Wed, Oct 29) | |
| 
                                        Chapman is dealing with an undisclosed injury and is uncertain to take the field for the Panthers.
                                     | |||
| D. Nunoo | LB | Questionable - Concussion ( Wed, Oct 29) | |
| 
                                        Nunoo is dealing with concussion protocol and is uncertain to take the field for the Panthers.
                                     | |||
| J. Lewis | WR | Out - Knee ( Thu, Oct 9) | |
| 
                                        Lewis is dealing with a knee injury and will miss the remainder of the 2025 season.
                                     | |||
| Offense | |||
|---|---|---|---|
| POS | # | Player | |
| QB | 1 | Keyone Jenkins | |
| RB | 5 | Kejon Owens | |
| WR | 4 | Alex Perry | |
| WR | 7 | Kyle McNeal | |
| WR | 19 | Ross Fournet | |
| TE | 88 | Jackson Verdugo | |
| OG | 54 | Chad Staley | |
| OG | 55 | Daniel Michel | |
| OG | 59 | Jaheim Buchanon | |
| OG | 71 | Antonio Tripp Jr. | |
| OG | 78 | Jaleel Davis | |
| Defense | |||
|---|---|---|---|
| POS | # | Player | |
| LB | 0 | Johnny Chaney Jr. | |
| LB | 11 | Percy Courtney Jr. | |
| DL | 19 | Olasunkonmi Agunloye | |
| DL | 25 | Kenton Simmons | |
| DL | 44 | Keegan Davis | |
| DL | 95 | Quaylen Hill | |
| CB | 2 | Brian Blades II | |
| CB | 4 | Victor Evans III | |
| CB | 22 | Shamir Sterlin | |
| CB | 23 | Jessiah McGrew | |
| CB | 27 | Mister Clark | |