MLS Predictions: Moneyline Picks for Every Matchday 21 Game

Jason Ence - Contributor at Covers.com
Jason Ence • Betting Analyst 13+ years betting experience
Updated: Aug 22, 2026 , 09:56 AM ET • 4 min read

Matchday 21 is here, headlined by a draw when the Vancouver Whitecaps face FC Dallas!

Cheick Sabaly of the Vancouver Whitecaps MLS
Photo By - Reuters Connect. Cheick Sabaly of the Vancouver Whitecaps MLS

Fixture congestion is hitting Major League Soccer clubs hard, and this weekend brings another full slate of 15 matches for Matchday 21.

Just four of 15 home sides claimed victory midweek, with eight away sides claiming all three points, but my MLS moneyline picks are backing the home sides to get back on track

Led by an entertaining showdown between Vancouver and Dallas, here are my free betting picks for Matchday 21!

MLS moneyline picks for Matchday 21

Game Pick
Orlando City SC Orlando City SC vs Real Salt Lake Real Salt Lake  Orlando City SC 49%
New York Red Bulls New York Red Bulls vs Chicago Fire Chicago Fire  Chicago Fire 41%
 CF Montreal CF Montreal vs LA Galaxy LA Galaxy  CF Montreal 46%
Inter Miami FC Inter Miami FC vs Toronto FC Toronto FC  Draw 13%
FC Cincinnati FC Cincinnati vs Seattle Sounders FC Seattle Sounders  FC Cincinnati 61%
Cardinals Charlotte FC  vs D.C. United D.C. United   Cardinals 54%
Cardinals St. Louis CITY SC vs Houston Dynamo Houston Dynamo  Houston Dynamo 29%
Nashville SC Nashville SC vs Columbus Crew SC Columbus Crew SC  Nashville SC 58%
Austin FC Austin FC vs Philadelphia Union Philadelphia Union  Philadelphia Union 46%
Vancouver Whitecaps FC Vancouver Whitecaps FC vs FC Dallas FC Dallas   Draw 19%
San Jose Earthquakes San Jose Earthquakes vs Minnesota United FC Minnesota United FC  San Jose Earthquakes 44%
San Jose Earthquakes San Diego FC vs Colorado Rapids Colorado Rapids  Draw 25%
Los Angeles FC LAFC vs Portland Timbers Portland Timbers  Draw 20%

Percentages courtesy of Kalshi, one of the best prediction market apps.

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Expert MLS moneyline picks for Matchday 20

Orlando City SC vs Real Salt Lake pick: Orlando City

Kalshi probability: 49%

Real Salt Lake was able to pull level with Dallas on Wednesday, but fell short after conceding in stoppage time. They've now taken just three points from their last six in MLS action and hit the road, where they've won just once in nine matches. Orlando were unfortunate not to win against Chicago, but they'll claim all three points here against an RSL side that will be looking ahead to Tuesday's League Cup fixture vs. Leon. 

NY Red Bulls vs Chicago Fire pick: Chicago Fire

Kalshi probability: 41%

Chicago's win in Orlando was their sixth victory on the trot in all competitions, their longest winning streak in 28 years. The Red Bulls are coming off their fourth home shutout defeat, and won't have the answers to stop Robert Lewandowski and the red-hot Fire.

CF Montreal vs LA Galaxy pick: CF Montreal

Kalshi probability: 46%

Despite playing with just 10 men for half the match, the Galaxy got a late goal to beat San Jose and get their first win since before the World Cup. However, they won despite allowing 2.36 xG, and now travel cross-country on short rest. CF Montreal will be poised to extend a four-match unbeaten run, while picking up just their sixth victory of the MLS season.

Inter Miami vs Toronto FC pick: Draw

Kalshi probability: 13%

Things got ugly at the end of Inter Miami's 2-2 draw with Philadelphia, and Yannick Bright is suspended as a result. Toronto will be without Walker Zimmerman, but will be bolstered by their comeback from 3-1 down against Charlotte while a man down. I cannot back Inter Miami at this number, not with how inconsistent they've been and how well Toronto have been battling of late, so I'll look to capitalize on the draw at this number.

FC Cincinnati vs Seattle Sounders pick: FC Cincinnati

Kalshi probability: 61%

Seattle's injury list is staggering, and there's simply not much more they can do given the players they're missing. Traveling across the country on short rest to deal with Evander is a tough situation, especially when having to defend the likes of Evander for 90 minutes. Cincinnati's 61% probability is juicy, but it's also warranted. 

Charlotte FC vs DC United pick: Charlotte FC

Kalshi probability: 54%

Charlotte still has to be wondering how exactly they dropped points against Toronto, but they've got no time to dwell on it with the short turnaround. That said, their improved offensive output of late will be enough to see off a DC United side that hasn't kept a clean sheet in nine matches and has scored just one goal over their past two outings.  

St. Louis City SC vs Houston Dynamo FC pick: Houston

Kalshi probability: 29%

Houston's win in Vancouver was their fifth-straight victory in MLS without conceding a goal, something only two other clubs have ever done in league history. It was also a statement win, and one I find hard to ignore. While St. Louis City is unbeaten in 10, their draw with Sporting KC showed they struggled to create chances without Marcel Hartel, and that will be their downfall here.  

Nashville SC vs Columbus Crew pick: Nashville

Kalshi probability: 58%

Nashville remain red-hot as they've now extended their lead in the race for the Supporters' Shield to seven points over Inter Miami, and they've taken 28 of a possible 30 points at home this season. The Crew looked tired against Montreal, and their attack generated just 0.31 xG despite dominating possession. They won't have the answers for this dangerous Nashville attack led by Sam Surridge.  

Austin FC vs Philadelphia Union pick: Philadelphia Union

Kalshi probability: 46%

Cavan Sullivan's red card was rescinded by MLS, and rightly so. He's in stellar form, and his creativity in the final third will be key to unlocking an Austin side that has conceded just nine goals in nine home matches. Austin's win in Seattle was a big one for them, but the fatigue of that long trip home combined with an inconsistent attack makes the Union the more likely play—especially with Austin having an eye on their Leagues Cup match in Toluca on Wednesday.

Vancouver Whitecaps vs FC Dallas pick: Draw

Kalshi probability: 19%

Life after Sebastian Berhalter isn't going as well as Vancouver hoped, and they had no answers in attack for Houston on Wednesday. Scoring goals shouldn't be an issue against a Dallas squad that doesn't mind getting into a track meet, but preventing them could be. Dallas has taken 20 points on the road, the most in the Western Conference, and Petar Musa is locked in. Look for him to add to his league-leading 16 goals as these clubs provide a highly entertaining contest with the teams sharing the spoils. 

San Jose Earthquakes vs Minnesota United FC pick: San Jose

Kalshi probability: 44%

Racking up 2.36 xG and failing to score is just nasty business, but it's what San Jose did against the Galaxy. It led to their fourth defeat in five, as they continue to slide down the table. Thankfully, they're in a good spot to pick up three points against a Minnesota that has not won in the league since May 2, a span of nine matches.  

San Diego vs Colorado Rapids pick: Draw

Kalshi probability: 25%

San Diego have won just three of their last 17 matches in the league, and host a Colorado Rapids side that have claimed three straight victories by way of a clean sheet. The hosts' desperation to remain in the hunt for a playoff spot should be enough to get them a result, but not enough to end Colorado's unbeaten run. 

LAFC vs Portland Timbers pick: Draw

Kalshi probability: 20%

LAFC managed just 0.41 xG against Colorado on Wednesday, as they heavily rotated their squad. That rotation may not be enough to take all three points against an improved Portland side, who have won the last two meetings and picked up 13 of 18 points over their last six matches. The Timbers will do enough to make this draw probability a great value play.

New England Revolution vs New York City FC pick: New England Revolution

Kalshi probability: 42%

The Revs got back to winning ways against DC United thanks to Alhassan Yusuf, whose hat trick saw them end a three-match winless streak. NYCFC have lost all confidence at the moment, losers of four straight in all competitions, and are not performing well defensively. Yusuf and new signing Jack Harrison will capitalize and help lead New England to victory. 

Atlanta United vs Sporting KC pick: Atlanta United

Kalshi probability: 59%

Sporting KC will be thrilled with getting a point off their rivals midweek at home, but they're still the worst away side in MLS, having conceded 31 goals while scoring just seven. Atlanta's won two on the trot, and could pull themselves off the basement of the Eastern Conference with a win. The probability is a bit juicier than I'd like, but Atlanta are correctly favored and should find attacking success against this poor Sporting back line.  

Jason Ence's 2026 Transparency Record
  • Moneyline picks: 97-134, -7.64 units

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Jason Ence - Covers
Betting Analyst

Jason has been hooked on football since watching Real Madrid and Manchester United in the 2003 Champions League, and has been betting on the sport for nearly 15 years. He has given soccer gambling and fantasy advice for nearly a decade, writing for sites including Rotowire, SB Nation, and The TwinSpires Edge.

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