Arsenal seek to maintain their perfect start to the Champions League when Atletico Madrid travel to the Emirates.
The Gunners are one of only two sides in the competition to win both of their first two matches without conceding a goal. Atletico will hope to reverse their road woes and pick up an away victory for the first time this season in any competition.
Read on for my free Arsenal vs. Atletico predictions and Champions League soccer picks on Tuesday, October 21.
Arsenal vs Atletico Madrid picks and predictions
My Arsenal vs Atletico Madrid best bet: Marcos Llorente 1+ shots (+115 at Sports Interaction)
While Marcos Llorente often lines up at right back for Atletico Madrid, don’t let that fool you into thinking he’s not a threat to shoot or score at any point.
For proof, look no further than Atletico Madrid’s last visit to British soil. Their first Champions League group stage match saw them fall 3-2 at Liverpool, but it was Llorente’s two goals that saw them level things after falling behind 2-0 in just six minutes.
And when Atletico concede possession, as they’re likely to do against Arsenal, he becomes even more of a threat. He typically helps drive the ball forward on the counter with his pace.
Over the past year, he ranks in the Top 10% of all major European league midfielders in progressive carries. This season, he’s averaging almost 2.5 touches per 90 minutes in the opposing penalty area across La Liga and Champions League.
Arsenal have yet to concede a goal in their two Champions League matches, and they’re limiting opponents' shooting opportunities. But when they lose the ball, they are prone to being hit on the break.
This is especially true down their left side when Riccardo Calafiori is playing at left back. I use the term “playing” loosely, as you’ll often find the Italian fullback in nearly any position he wants to be in at any given point in a match.
The price of +115 is extremely kind, as Llorente should probably have even money odds at best to take a shot. And if Atletico line up in a 3-5-2 as some reports are suggesting, that price becomes even more of a gift.
Arsenal vs Atletico Madrid same-game parlay (SGP)
Marcos Llorente 1+ shots
Gabriel Magalhaes 1+ shots
Arsenal moneyline
Everyone knows Arsenal’s fondness for set pieces, and this match should give them plenty of opportunities to send their big men into the box. Atletico Madrid like to foul and play compact, especially on the road, and that should lead to both free kicks and corners.
Despite being a center back, Gabriel Magalhaes is averaging 0.88 shots per 90 minutes in the Premier League this season. Look for him to get on the end of a cross and test Jan Oblak at some point.
Arsenal have six consecutive victories over Spanish clubs in the Champions League, and Atletico Madrid have been fairly poor in their travels this season. The Gunners will push their overall winning streak for the campaign to six as they claim all three points.
Arsenal vs Atletico Madrid odds
Arsenal vs Atletico Madrid odds
 Arsenal |
 Atletico Madrid |
|
|---|---|---|
| -165 | Moneyline | +450 |
| +300 | Draw | +300 |
| Over 2.5 (-115) | Total | Under 2.5 (-120) |
Odds courtesy of Sports Interaction.
How to watch Arsenal vs Atletico Madrid
| Location | Emirates Stadium, London, UK |
| Date | Tuesday, October 21, 2025 |
| Time | 3:00 p.m. ET |
| TV | Paramount+ |
| Weather | 56F, 10-12 mph winds, PoP 18% |
Arsenal vs Atletico Madrid key injuries
Arsenal: Martin Odegaard M (Out), Gabriel Jesus F (Out), Kai Havertz M (Out), Noni Madueke F (Out).
Atletico Madrid: Johnny Cardoso M (Doubtful), Nicolas Gonzalez M (Doubtful).
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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