The path to Super Bowl LX is narrowing as eight titans collide in a high-stakes Divisional Round weekend. From the thin air of Denver to the hostile environments of Foxborough and Chicago, these fiercely proud franchises will be laying it all on the line.
We’ve crunched the numbers, simulated the matchups, and identified the sharpest edges on the board using our AI-powered Covers Predictions tool. Whether you’re looking for a lock or a live underdog, our NFL picks have you covered.
NFL Divisional Round picks
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Lines courtesy of FanDuel.
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Bills vs Broncos
Buffalo enters as the No. 6 seed but brings the league’s top-ranked rushing attack (159.6 YDS/G) and the No. 1 passing defense (allowing just 156.9 YDS/G). They face a 14-3 Broncos squad that secured the AFC’s top seed behind a defense ranking second overall (278.2 YDS/G).
Despite Denver's rest, the AI likes the Bills to cover +1.5 and win outright, banking on their momentum to stifle the Broncos' home-field advantage in a low-scoring affair (Under 47).
View our matchup Bills vs. Broncos matchup hub for more stats and analysis prior to kickoff.
49ers vs Seahawks
In this fierce NFC West rematch, the AI is calling for a Seattle moneyline win as a 7.5-point favorite. The Seahawks finished the season on a 7-game winning streak to clinch the No. 1 seed, led by receiving leader Jaxon Smith-Njigba (1,793 yards).
While the 49ers boast a Top-5 passing offense, Seattle’s balanced Super Bowl odds (19%) and home dominance suggest they’ll pull through in a high-scoring shootout (Over 45.5).
Check out our 49ers vs. Seahawks matchup hub before game time.
Texans vs Patriots
This is a classic "best vs. best" matchup: Houston’s No. 1 ranked total defense (277.2 YDS/G) against New England’s No. 3 offense, which led the league in total passing yards.
The Patriots ended the regular season with a 14-3 record and a No. 2 seed, and the AI backs the Pats as 3.0-point home favorites, predicting their prolific air attack will eventually crack the Texans' stingy secondary.
Looking for more analysis? Check out our Texans vs. Patriots matchup hub.
Rams vs Bears
The Rams' No. 1 ranked offense (394.6 YDS/G) meets Chicago’s physical ground game (No. 3 rushing offense). While Matthew Stafford led the NFL with 4,707 passing yards, the AI expects a tactical, lower-scoring battle (Under 50.5).
Look for the Rams to lean on their experience to cover the 3.5-point spread on the road against a Bears team that stumbled late with two consecutive losses to end the regular season.
Find more stats, results, and trends on our Rams vs. Bears matchup hub.
Odds are correct at the time of publishing and are subject to change.
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