The Ohio State Buckeyes took care of business in their season opener, beating Minnesota, and now, they follow that up with a big non-conference matchup as the Oregon Ducks come to the Horseshoe.
Meanwhile, the Ducks struggled to put away Fresno State last week as big favorites and, as a result, will be two-touchdown underdogs for this matchup. Can the Buckeyes keep rolling, or is there value with the Ducks as dogs in this matchup?
Find out with our free college football betting picks and predictions for Oregon vs. Ohio State on Saturday, September 11.
Oregon vs Ohio State odds
Odds via the Covers Line, an average comprised of odds from multiple sportsbooks.
Ohio State opened this matchup as a 14-point home favorite and has been moved up a half-point to -14.5. Meanwhile, the total hit the board at 64, was bet down as low as 62.5, and has bounced back to 63.5. Be sure to check out the full college football odds before placing your bets, and also view the full line movement for this game.
Oregon vs Ohio State picks
Picks made on 9/8/2021 at 1:35 p.m. ET.
Click on each pick to jump to the full analysis.
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Oregon vs Ohio State game info
• Location: Ohio Stadium, Columbus, OH
• Date: Saturday, September 11, 2021
• Time: 12:00 p.m. ET
• TV: FOX
Oregon vs Ohio State betting preview
Be sure to monitor the gametime conditions with our NCAA football weather info.
Oregon: Troy Franklin WR (Probable), Kayvon Thibodeaux DE (Questionable).
Ohio State: Cameron Brown CB (Questionable), Sevyn Banks CB (Questionable), Harry Miller OL (Questionable).
Find our latest NCAA football injury reports.
Betting trend to know
Ohio State is 1-5 ATS in its last six games at home. Find more NCAA betting trends for Oregon vs. Ohio State.
Oregon vs Ohio State predictions
Oregon +14.5 (-110)
CJ Stroud might not have exactly looked the part of the next great Ohio State quarterback in the Buckeyes 45-31 win over Minnesota, but with the weapons surrounding him, it might not matter.
Stroud completed just 13 passes in the win, but they went for 294 yards and four touchdowns thanks to stud wideouts Chris Olave and Garrett Wilson.
The Buckeyes’ dynamic duo combined to haul in nine receptions for 197 yards and three scores. While blue-chip running back TreVeyon Henderson scampered for a 70-yard catch-and-score. Miyan Williams led the way on the ground, rumbling for 125 yards and a touchdown on just nine carries.
If there was a concern for Ohio State, it was that Golden Gophers running back Mohamed Ibrahim was rumbling all over them before suffering a devastating lower-leg injury. Minnesota was actually leading before he left the game, and the Ducks are more talented on paper than the Gophers.
Oregon got out to a fast start against Fresno State, going up 14-0 in the first quarter, but was never able to pull away in a game where it was a 17.5-point favorite. In fact, the Ducks trailed at one point in the fourth quarter.
That said, it’s a solid bet that if we look back at this game at the end of the season, Fresno State might end up being a much better team than initially thought.
The Ducks have plenty of talent on defense, led by a potential No. 1 overall pick in next April’s NFL Draft, Kayvon Thibodeaux (listed as questionable). The Ducks managed four sacks last week, and if they can force Stroud into some tough throws, they’ll have a chance to keep this one close.
On offense, the Ducks were led by Anthony Brown, who threw for 172 yards and a score while adding another 56 yards and a score on the ground. Expect Oregon to try and keep the Ohio State defense off-balance with Brown’s versatility and then feed them a heavy dose of running backs CJ Verdell and Travis Dye.
The Ducks have a chance to bring the Pac-12 back to the College Football Playoff this season, and a strong performance in Columbus could go a long way towards that. Ohio State should pull away late, but Oregon has the talent to cover the two touchdowns.
Under 63.5 (-110)
The early money on the total for this high-profile non-conference matchup has come in on the Under before bouncing back close to the opening number, and we’re inclined to side with the early money.
This game features two very talented defenses. Thibodeaux and Co. should be able to provide enough pressure on Stroud to keep them from getting burned by Olave and Wilson too often. Don’t get me wrong, they’ll get theirs, but the Ducks have a chance to limit the times it happens. Meanwhile, Ohio State did a great job limiting Tanner Morgan to intermediate, over the middle passes, allowing just 205 yards passing.
Because of this, both teams will look to establish the run in this game, milking the clock in the process. With the Under also going 10-1 in Oregon's last 11 games as a road underdog and 7-3-1 in Ohio State's last 11 against teams with a winning record, we like the trends to continue.
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