The action and odds are looking a little different for this year’s U.S. Open, which begins Monday in New York.

Noticeably absent is Rafael Nadal, out with a knee injury, and Andy Murray’s recent gold medal success in London has bettors believing the Scotsman could finally win his first grand slam.

“For Murray, we did see a spike in the action, and a drop on the odds for him after the gold medal win, as well as after Nadal pulled out,” says Aaron Black of bet365.com. “That scenario has changed with the release of the draw and a possible semi final matchup between Murray and Federer. More bettors have jumped on Federer , which has seen his price drop to +250 from +300, and Murray has drifted to +333 from +275.”

Federer and Murray got pulled on the same side of the draw, which could set up a semifinal that might be more anticipated than the final itself. Federer beat Murray in the Wimbly final this year and Murray toppled Fed at the Olympics for the top prize.

Novak Djokovic (+138), who is the defending champ here, is aiming to reach his third straight final at the last grand slam of the season.

This year will mark the first time since 2008 that Roger Federer, Nadal, Djokovic and Murray haven't been seeded 1 through 4 in some way at this event. As a result, Black says Juan Martin Del Potro (+1000), Milos Raonic (+4000), Jo-Wilfried Tsonga (+3300) and John Isner (+5000) are seeing some sprinklings of action, though the majority is on the big three.

As for American fan favorite Andy Roddick? Well, he’s starting to become better known as Brooklyn Decker’s husband.

“Very little action (on Roddick),” says Black. “Before the last 2 seasons, we would have always seen some action on him to win either Wimbledon or the US Open, but even at +10000, the action is nothing to speak of.”