Both teams hope for direct qualification, which means securing a Top-8 spot in the Champions League rankings after the eighth week. Chelsea currently sit 12th, while Barcelona are just in front thanks to a higher goal difference, but on the same number of points.
Given the attacking quality on display, this can be a top watch even for neutrals. I'll be opting for goals in my Chelsea vs. Barcelona predictions and free betting picks for Tuesday, November 25.
Chelsea vs Barcelona picks and predictions
My Chelsea vs Barcelona best bet: Over 3.5 (+100 at Sports Interaction)
Barcelona hit the net 12 times in the four games they played so far in the Champions League. This is a dangerous team up front, and the fact that they now have Yamal and Lewandowski back in fitness means extra firepower in the opposite box.
Chelsea conceded six times in their four matches, so they're not a defensive machine. It will take something very special from Enzo Maresca's defenders to keep Barcelona quiet.
Instead, the Italian manager will focus on harming his team's glamorous opponents rather than trying to contain them. The Londoners will look to punch from the wing, where they count on electric raids and plenty of quality.
Barcelona have scored at least three goals in five of their last six games in all competitions. In their previous Champions League encounter, away against Club Brugge, they saved a point dramatically in a spectacular 3-3 draw. Their weaknesses were exposed, and Chelsea can surely exploit them based on what they've seen.
I'll be going for the Over 3.5 goals, which SIA pays at +100.
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Chelsea vs Barcelona same-game parlay (SGP)
Over 3.5
Robert Lewandowski 2+ shots on target
Joao Pedro 2+ shots on target
In the last two La Liga matches he featured in, Lewandowski scored a combined total of four goals. Because of injury, his impact in the Champions League was reduced to zero this season. He'll be heavily involved at Stamford Bridge, and I count on him to try and take centre stage against Chelsea. In fact, he scored 11 goals in 13 UCL outings last season.
Joao Pedro is also after his first Champions League goal, so there's pressure on him to deliver. The €65 million summer arrival scored four times for Chelsea in the Premier League, but has yet to get his name on the scoresheet in Europe. The Brazilian likes big matches, and I'm counting on his hunger to deliver at the highest level.
Chelsea vs Barcelona odds
 Chelsea |
 Barcelona |
|
|---|---|---|
| +125 | Moneyline | +175 |
| +290 | Draw | +290 |
| Over 2.5 (-250) | Total | Under 2.5 (+170) |
Odds courtesy of Sports Interaction.
How to watch Chelsea vs Barcelona
| Location | Stamford Bridge, London, England |
| Date | Tuesday, November 25, 2025 |
| Time | 3:00 p.m. ET |
| TV | Paramount+ |
Chelsea vs Barcelona key injuries
Chelsea: Levi Colwill CB (Out), Romeo Lavia CM (Out), Cole Palmer FW (Out).
Barcelona: Pedri CM (Out).
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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