NFL Bettors Backing Favorites in Divisional Matchups in Week 11

The 49ers, Vikings, and Chiefs are seeing heavy action as favorites in games within their division, but a non-divisional contest between the Lions and Eagles in prime time is also getting some love.

Brad Senkiw - Contributor at Covers.com
Brad Senkiw • News Editor
Nov 14, 2025 • 16:46 ET • 4 min read
Photo By - Imagn Images.

Week 11 in the NFL features eight divisional showdowns, and three of the most-bet games at BetMGM involve teams sharing that kind of familiarity.

Key Takeaways

  • The 49ers, Vikings, and Chiefs are heavily bet favorites in divisional matchups.

  • A prime-time game between the Lions and Eagles is seeing plenty of action.

  • The Dolphins are a popular pick in the final European game of 2025.

“Bettors are focused on division matchups in Week 11,” said Christian Cipollini, BetMGM trading manager. “The Vikings, 49ers, and Chiefs covering as favorites would be great for customers. A few underdogs being competitive would help the sportsbook.” 

San Francisco is the most-bet team by both handle and tickets at the online sportsbook. The 49ers are 3-point favorites at NFC West opponent Arizona, and the road team is getting 89% of the bets and 93% of the money. 

Minnesota, the second most-bet team by handle at BetMGM, is attracting nearly 75% of the money as a 2.5-point favorite in its NFC North matchup with the Bears. The Kansas City Chiefs are 3.5-point favorites and are receiving the second-most tickets and the third-highest handle of any team this week in an AFC West showdown against Denver.

In other divisional matchups, sportsbooks are seeing split action on Panthers-Falcons, while Bengals-Steelers has taken different routes at DraftKings and BetMGM. The Ravens (-7.5) are a popular pick to beat the Browns, and the Rams are getting a huge bulk of the money as 3-point favorites against the Seahawks.

Week 11 Games DraftKings Splits BetMGM Splits
Commanders-Dolphins (-2.5) MIA 77% bets
MIA 80% handle
MIA 79% bets
MIA 79% handle
Packers-Giants (+7) GB 68% bets
GB 72% handle
GB 71% bets
GB 74% handle
Buccaneers-Bills (-5.5) TB 56% bets
BUF 69% handle
BUF 58% bets
BUF 72% handle
Texans-Titans (+6) HOU 65% bets
TEN 62% handle
HOU 64% bets
HOU 66% handle
Bengals-Steelers (-5.5) CIN 60% bets
CIN 54% handle
PIT 60% bets
PIT 66% handle
Chargers-Jaguars (+3) LAC 74% bets
LAC 63% handle
LAC 65% bets
LAC 51% handle
Bears-Vikings (-3) CHI 52% bets
MIN 54% handle
MIN 61% bets
MIN 64% handle
Panthers-Falcons (-3.5) ATL 59% bets
CAR 58% handle
CAR 51% bets
ATL 50% handle
Seahawks-Rams (-3) LAR 56% bets
LAR 90% handle
LAC 61% bets
LAC 76% handle
49ers-Cardinals (+3) SF 81% bets
SF 86% handle
SF 89% bets
SF 93% handle
Ravens-Browns (+7.5) BAL 75% bets
BAL 79% handle
BAL 62% bets
BAL 56% handle
Chiefs-Broncos (+3.5) KC 63% bets
KC 86% handle
KC 55% bets
KC 60% handle
Lions-Eagles (-2.5) DET 66% bets
DET 53% handle
DET 67% bets
DET 59% handle
Cowboys-Raiders (+3) DAL 79% bets
DAL 81% handle
DAL 81% bets
DAL 84% handle

Prime-time showdown 

One of the most intriguing games for bettors in Week 11 is an out-of-division showdown between the Lions and Eagles. Detroit heads to Philadelphia on Sunday night in the most-bet game at BetMGM as a 2.5-point underdog. 

Tickets and money are both leaning toward the Lions at DraftKings and BetMGM, but there is still enough coming in on the Eagles to keep Detroit’s percentages in the 60s. 

However, the Lions are the most-bet moneyline underdog this week at BetMGM, and the over 46.5 cracks the top five most popular totals. Philadelphia receiver A.J. Brown’s 58.5 receiving yards is the operator’s most-bet player prop. 

Riding the hot hand

The final NFL game in Europe for 2025 takes place early Sunday between the Commanders and Dolphins from Madrid, Spain. It’s no surprise that more than 70% of the tickets and money are on the 2.5-point favored Dolphins, who are coming off a massive outright upset of the Bills last week. 

Washington, meanwhile, has lost by 20 or more points in four consecutive games, leaving just 26% of the moneyline bettors at DraftKings willing to back the underdog outright. Just 20% of the spread handle is on the Commanders.

Popular picks

The Packers (-7) are one of the five most-bet teams by handle at BetMGM against the Giants, while the Cowboys (-3) are also among that group in tickets when they face the Raiders on Monday night in Las Vegas.

Green Bay is seeing over 70% of the handle, and Dallas is seeing even more with over 80% of the money. 

The Texans are expectedly seeing love as 6-point favorites in their AFC South matchup with the 1-8 Titans. At BetMGM, Houston is getting over 64% of bets and handle, but DraftKings reported Tennessee has seen 62% of the tickets so far. 

Underdogs, totals

The Broncos (+170), Bears (+125), Commanders (+130), and Bucs (+200) make up the other most-bet moneyline underdogs at BetMGM. 

Chiefs-Broncos under 45, Bucs-Bills under 47.5, and Ravens-Browns under 39.5 are the three most-bet totals for the operator. 

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Brad Senkiw - Covers
News Editor

Brad has been covering sports betting and iGaming industry news for Covers since 2023. He writes about a wide range of topics, including sportsbook insights, proposed legislation, regulator decision-making, state revenue reports, and online sports betting launches. Brad reported heavily on North Carolina’s legal push for and creation of online sportsbooks, appearing on numerous Tar Heel State radio and TV news shows for his insights.

Before joining Covers, Brad spent over 15 years as a reporter and editor, covering college sports for newspapers and websites while also hosting a radio show for seven years.

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