Seattle -2.5 is the pick here. Injuries on the S.F. side have taken away too much from their strength. Purdy will be much more susceptible to being blitzed and sacked without the protection he used to enjoy. He will be more rushed in his play making decisions which will lead to game changing turnovers. His offensive targets are reduced, Kittle is probably back but I doubt he's that close to healthy enough to perform like he had been. McCaffrey has been used so much that he also hasn't had time to heal and recover from all his aches and pains. They will not spend the expense of over using him this game. The Niners are going to face a very strong defense for a change, and Seattle's offense is strong and healthy enough to get the win against 49er's mediocre and reduced defense. We are going to see a 49ers injury burdened offense that wont look as strong against Seattle's overwhelming defense. And Seattle will do fine offensively, as they have been. Enjoy the game.
on your play Happy New Year 
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