MacIntyre led Colorado to the Pac-12 championship game and earned AP College Football Coach of the Year honors in 2016.
He is 30-44 overall as the Buffaloes' coach.
George said he will name an interim coach for the final game against California in Berkeley. If Colorado wins, the team would be bowl eligible.
For the permanent job, George wants to hire a recognizable name with previous head-coaching experience, sources told ESPN's Adam Rittenberg. Possible candidates include former Oregon coach and Chicago Bears offensive coordinator Mark Helfrich, Fresno State coach Jeff Tedford, Boise State coach Bryan Harsin, and West Virginia coach Dana Holgorsen, who may be interested in making a move after the season.
MacIntyre's contract runs through 2021 and has $10.3 million remaining.
Funny that the Boise coach is on the list. I remember what happened the last time they took a Boise coach (Dan "This ain't intramurals, brotha!" Hawkins).