CINCINNATI -- Catcher Yadier Molina hit a solo home run and right-hander Adam Wainwright pitched seven scoreless innings, lifting the St. Louis Cardinals to a 1-0 Opening Day victory over the Cincinnati Reds on Monday afternoon at Great American Ball Park.
Wainwright (1-0) earned his 100th career victory by allowing just three hits and striking out nine.
Right-hander Trevor Rosenthal earned the save with a 1-2-3 ninth inning. The Cardinals won despite committing three errors.
Reds right-hander Johnny Cueto (0-1) allowed just three hits and struck out eight in seven innings, but also gave up Molina's homer. Cueto issued one walk.
Cueto retired eight straight Cardinals batters following first baseman Matt Adams' second-inning single.
The only two hits allowed by Cueto through five innings were by Adams, who singled and doubled down the third-base line with the Reds' infield shifted to the right side.
Third baseman Frazier had the only two hits for Cincinnati through four innings off Wainwright, whose off-speed pitches kept the Reds off balance for much of the game.
Wainwright walked two in the sixth and tossed a wild pitch. But shortstop Zack Cozart grounded out to strand runners at first and second.
With one out in the seventh, Molina launched Cueto's first pitch an estimated 368 feet into the left field stands, putting St. Louis ahead 1-0.
Molina's homer was all the offense the Cardinals would need, but Cincinnati had its chances.
The Reds twice had the tying run on third base in the eighth inning but could not score.
Second baseman Brandon Phillips was retired in a rundown after leaving on contact on right fielder Jay Bruce's ground ball to first. First baseman Joey Votto was left stranded at third when right-hander Carlos Martinez fanned Frazier looking to end the inning.
NOTES: Monday's game was the 138th Opening Day in the storied history of the Cincinnati Reds franchise. ... Big Red Machine SS Dave Concepcion and Hall of Fame SS Barry Larkin threw simultaneous ceremonial first pitches prior to Monday's game. ... The Reds began the season with eight players on the disabled list, their most since 2007. ... Bryan Price made his debut as Reds manager after spending the previous four seasons as pitching coach. "It can be a little overwhelming if you allow it to be," Price said of his debut. "I'm going to embrace the moment. Going through this for the first time as a manager is special." ... Cardinals SS Jhonny Peralta is the eighth different Opening Day shortstop in eight seasons for St. Louis. ... The Reds had gone 60 straight Opening Days without being shut out.