The first week or so of preseason games are almost totally random. Each team uses about 6 pitchers per game, and most of them won't make the team. The regulars that do start usually don't play more than four or five innings or so all close games are decided at the end by a bunch of random minor leaguers, both on the mound, and at the plate and on the field. The ONLY angle I would bet in the first week of preseason is that games are almost totally random and I'll take significant plus money. Win about half the games or a bit less and hopefully clear a profit. Later in the preseason, as the pitchers stretch out to 3, 4, 5 innings, I'll start to pay attention to who is starting, look for matchups between pitchers who have had several decent outings with guys who have been slowed by injury and aren't as far along. And regular players will start playing more so I'll start avoiding the road teams where some of the best players don't make the trip.
But for now, it's nothing but a diet of big dogs, hope to get about half of them, and make a little bit:
Friday February 23
Tigers +146 vs Yankees (BetDSI)
White Sox +140 vs Dodgers (BetDSI)
Reds +130 vs Indians (BetDSI)