Blue Jays 6, Rays 2: Yunel Escobar belted a solo home run in the sixth inning to snap a tie and lead Toronto to victory in the opener of the three-game series.
Escobar and Colby Rasmus each had two hits and scored twice for the Blue Jays, who have won five of six.
With one out, Escobar drilled Jeremy Hellickson's first offering over the wall in left-center field for his second homer of the season and a 3-2 lead.
Toronto added three runs in the eighth to seal the win for Kyle Drabek (4-4), who allowed two runs and three hits in six innings. The right-hander struggled with his control, however, issuing a season high-tying six walks.
B.J. Upton gave the Rays a 1-0 lead in the first inning, but not without the help of video replay. Upton had a double changed to a home run as his fly ball hit a catwalk high above the playing field.
Hellickson (4-1) suffered his first loss in three career decisions against the Blue Jays, yielding five runs - two earned - and eight hits over 7 1/3 innings.
Will Rhymes recorded two of the five hits by Tampa Bay, which has lost four of five.
GAME NOTEBOOK: Drabek has issued four or more walks in each of his last four starts. He uncorked three wild pitches, all in the third inning, to raise his season total to seven. Henry Rodriguez of Washington began the day leading the major leagues with six wild pitches. ... Hellickson has allowed two earned runs or less in seven of his nine starts this year. ... Rays C Jose Molina, who left Sunday's game after being hit hard in the mask with a ball, was back in the lineup and went 0-for-2 with two walks. ... Tampa Bay is 4-2 against Toronto this season.