If you're looking to get some action down but only have a few minutes to handicap, let our Top-25 cheat sheet help you out. We grab the best quick-hitting betting info on each of the Top 25 matchups with odds available in Week 10 of the season.
Missouri at (8) Florida (-17, 42.5)
Gators QB Jeff Driskel had his worst game of the season in a back-breaking defeat to Georgia last week, committing four of Florida's six turnovers. While the Tigers' struggling offense should get a boost with the return of starting QB James Franklin, who came on in relief of Corbin Berkstresser in the third quarter of last week's game. Franklin had been sidelined since spraining a medial collateral ligament in his left knee in a home loss to Vanderbilt on Oct. 6. The Gators are 6-1 ATS in their last seven games overall.
(12) Oklahoma at Iowa State (11.5, 52.5)
Oklahoma saw its slim national championship hopes evaporate last week with a loss to Notre Dame. The No. 12 Sooners will try to shake off the disappointment and earn a 14th straight victory over Iowa State at Jack Trice Stadium. The Cyclones hold the longest home losing streak in the country to a single opponent vs. the Sooners, a span of 20 games. Their last home win against Oklahoma came Nov. 5, 1960. Oklahoma is 19-0 following a loss since 2004 and hasn’t lost to Iowa State in 22 years. The Cyclones have relied on a defense that has generated the second-most turnovers in the Big 12 (19). But star LB James Knott is out for the season after undergoing shoulder surgery Monday. Knott had 11 tackles and a forced fumble in a victory over Baylor last week. The teams have played under the total in their last four meetings.
Temple at (10) Louisville (-15.5, 51)
The Cardinals are one of six unbeaten teams, thanks mostly to their efficiency in the red zone. Louisville has come away with points in 33 of 34 trips to the red zone, second in the nation behind Alabama. Temple has allowed 82 points in the last six quarters in two losses and is searching for more consistency its offense while it tries to avoid its first three-game losing streak since 2008. The Cardinals are 1-4 ATS in their last five games overall.
(16) Texas A&M at (18) Mississippi State (7, 59)
Texas A&M will test its third-ranked scoring offense against Mississippi State’s stingy defense as both schools try to stay in the running for second place in the SEC West. The Aggies’ only two losses came at home against Florida and LSU by a total of eight points. Texas A&M is 1-11 ATS in its last 12 vs. a team with a winning record.
(15) Stanford at Colorado (27.5, 51)
The Cardinal can still claim the Pac-12 North Division title but will likely have to win out. Struggling first-string QB Josh Nunes will share the load with redshirt freshman Kevin Hogan, who is expected to play up to 20 snaps this week. Colorado has been outscored 213-51 during a four-game losing streak - 120-20 in the last two weeks after a 70-14 loss at Oregon - and has allowed the most points in the country among FBS teams (46 per game). The Buffaloes are 0-4 ATS in their last four home games.
TCU at (19) West Virginia (-6.5, 68)
The Mountaineers have fallen on hard times, dropping two straight games by a combined score of 114-28. The West Virginia defense has surrendered 1,155 total yards during that stretch, including 841 through the air. The Horned Frogs held a 14-0 lead at Oklahoma State last Saturday before allowing 36 unanswered points. They committed 10 penalties and had three turnovers as TCU was held to less than 20 points for the first time since the 2010 Fiesta Bowl, a string of 33 games. The Horned Frogs are 1-4 ATS in their last five games overall.
Pittsburgh at (4) Notre Dame (-16.5, 45.5)
Notre Dame is ranked third in the BCS standings thanks to a massive win at Oklahoma last week and has the schedule strength to possibly reach the national championship game should they win out. The Irish stop unit is allowing only 9.9 points - second to the Crimson Tide in the country. The Pittsburgh defense hasn’t been too shabby either, allowing just 23 total points over its past two contests. The Panthers have played under the total in their last six road games.
(22) Texas at (20) Texas Tech (-7.5, 67)
Texas Tech looks to bounce back after suffering a 55-24 thrashing at Kansas State while Texas needed a late rally to hold off one-win Kansas, 21-17 last weekend. The Longhorns’ defense is surrendering 218 yards rushing per game (108th in the country) while also sporting their worst marks in total (96th) and scoring defense (97th). Head coach Mack Brown announced this week that QB David Ash would remain the starter, despite being picked off twice and was pulled against the Jayhawks. Texas Tech QB Seth Doege leads the nation with 30 touchdown passes and is one of seven quarterbacks in FBS completing at least 70 percent of his passes. The Longhorns have failed to cover in their last four games.
Mississippi at (6) Georgia (-14, 62.5)
The Bulldogs upended the Gators last week and can win the East for the second consecutive season with victories in their final two conference games. Georgia ranks fifth in the SEC in rushing and fourth in passing, a balanced attack that has the offense averaging 36.8 points this season. The Rebels have allowed 27 or more points in three of their four conference games. But Mississippi went 4-0 ATS in those contests and is 5-0 ATS in its last five overall.
(21) Nebraska at Michigan State (2, 44.5)
Nebraska has won five of its last six and two straight since it was annihilated at Ohio State 63-36 on Oct. 6. This game will be a contrast in styles, pitting a high-powered Cornhuskers offense that leads the Big Ten in scoring against a rugged Spartans defense that ranks fifth nationally in total yards, allowing 267.4 per game. Michigan State's last five games have been decided by a total of 13 points and the Spartans have been limited to 16 points or fewer four times in that span. The Cornhuskers are 4-0 ATS in their last four meetings.
Texas-San Antonio at (23) Louisiana Tech (-32, 73)
The Bulldogs, who were held to fewer than 44 points for the first time all season last week in a win over New Mexico State, rank second in the country in total and scoring offense and have converted 48 of their 56 red-zone drives into points. Louisiana Tech has more red-zone touchdowns (44) than 115 FBS schools have red-zone trips. The Bulldogs' last seven games have played over the total and they're 11-2-1 ATS in their last 14 games following a win.
(9) Clemson at Duke (13, 65)
Clemson continues to build its resume for a BCS bowl bid, led by a high-octane offense. The ninth-ranked Tigers, averaging 41 points, go for their fifth consecutive victory at upstart Duke on Saturday. The Blue Devils could be without senior QB Sean Renfree, who suffered concussion-like symptoms in a 48-7 loss at Florida State last Saturday. Clemson has won eight of the last nine meetings and is 4-0 ATS in its last four road games.
(2) Oregon at (17) USC (7.5, 70)
The Ducks take their 12-game road winning streak to the Los Angeles Coliseum on Saturday to face the Trojans. The Ducks have rolled through their early schedule, winning their first eight games by at least 17 points, but they're set to face three Top 25 teams this month, including a pair against North Division rivals Stanford (home) and Oregon State (road). USC has little margin for error left in its quest for a Pac-12 South Division title after last week's 39-36 loss in which Arizona scored 26 consecutive points to rally from a 15-point second-half deficit. The Trojans have played under the total in their last five home games.
(24) Oklahoma State at (3) Kansas State (-10, 66)
The Wildcats look to keep their national title hopes alive Saturday against visiting Oklahoma State, which has won three straight. If the Wildcats can get past the Cowboys, they’ll only have one game left against a team with a winning record. The Cowboys lead the country in total offense, averaging 586.1 yards per game and are ranked sixth nationally in scoring at 44.3 points. Kansas State has outscored its opponents 216-67 in the second half, including 98-25 in the third quarter. The underdog is 4-1 ATS in their last five meetings.
(1) Alabama at (5) LSU (9.5, 41.5)
The undefeated Tide have won every game by at least 19 points and just demolished a very good Mississippi State team. Alabama leads the nation in scoring defense (8.1), while LSU ranks ninth (14.6). The fifth-ranked Tigers had a week off to prepare following wins over ranked foes South Carolina and Texas A&M. Under Les Miles, LSU is 36-1 in Saturday night home games and has won a school-record 22 straight in Death Valley. The road team is 13-3-1 ATS in their last 17 meetings.
San Diego State at (14) Boise State (-13.5, 49.5)
The Aztecs have won four straight games and are looking to participate in a postseason bowl game for the third straight year, something never previously accomplished in school history. The Broncos will be without two defensive starters in sophomore S Lee Hightower (suspension) and sophomore CB Bryan Douglas (season-ending knee injury). The Broncos pitched five consecutive first-half shutouts before allowing a touchdown to Wyoming on Oct. 27. Boise State has allowed only 26 points in the first half this season.
Arizona State at (13) Oregon State (-4, 54.5)
The Beavers are switching their starting quarterback, giving Cody Vaz the nod after Sean Mannion was intercepted four times in last weekend’s upset loss to Washington. Vaz will be up against the third-stingiest pass defense in the nation and the second-ranked team in sacks. The Wildcats are hoping two key pieces of their defense are back against Oregon State. Defensive lineman Will Sutton, who leads the team in sacks (8.5), suffered a bone bruise to his knee during the first series against Oregon two weeks ago and DE Junior Onyeali is aiming to return from a shoulder injury that has forced him to depart the last two games. The teams have played over the total in five of their last six meetings.