49ers vs RAMS AI Prediction OVER 45

According to an AI model by Microsoft Copilot, the score prediction for the Week 5 matchup on Thursday, October 2, 2025, is a  victory for the Los Angeles Rams over the San Francisco 49ers.

• 49ers' injuries: The San Francisco team is "significantly banged up" heading into the game, with key offensive and defensive players sidelined. Quarterback Brock Purdy has been ruled out with a toe injury, and receivers Ricky Pearsall and Jauan Jennings are also out. This is also an issue on defense, with Nick Bosa injured.
• Rams' home advantage: The Rams are seen as the healthier team, which is often a decisive factor in short-week games. With the game at SoFi Stadium, the Rams have the home-field advantage.
• Rams' hot start: The Rams were 3-1 going into the game and have been finding ways to win, including a victory over the then-undefeated Indianapolis Colts in Week 4. They are also 4-1 against the spread in their last five games.

OVER 45

I give you a full prediction of copilot.

Final Take

Most models hover around 46–47 points, aligning with the Vegas total. However, with injuries to key 49ers players (Nick Bosa, George Kittle, Brandon Aiyuk), and the Rams’ offense clicking behind Matthew Stafford and Puka Nacua, some experts lean slightly over the line.

If you’re betting:

• Lean Over 46.5 if you expect a shootout or late scoring
• Lean Under if you trust the 49ers’ defense to slow Stafford down

@Ilovefootballs

 Glad you agree. Im also leaning to the RAMS TT  also OVER 26