NFL Week 6 Odds and Betting Lines: Cowboys Stand as Slim Road Faves ahead of Clash in SoFi

NFL Week 6 brought plenty to the table, with some good — and bad — primetime matchups, as well as another early wake-up call in London on Sunday morning.

Week 6's Sunday NFL odds kicked off with the Baltimore Ravens and Tennessee Titans at 9:30 a.m. ET in the U.K., and came to a close with a SNF football clash between the New York Giants and Buffalo Bills that only a bettor could appreciate. The day came to a close with no undefeated teams left in the league.

Week 6 betting wraps up with a non-conference clash between the Los Angeles Chargers and Dallas Cowboys at SoFi Stadium on Monday night.

Here's a look at the current NFL Week 6 odds, and insights into those opening numbers.

NFL Week 6 odds, lines, and spreads

These are the NFL odds for Week 6, headlined by the Giants-Bills Sunday evening clash, and a showdown between the Cowboys and Chargers on Monday Night Football.

Ravens/Titans will be in London, England.
Bye: Green Bay, Pittsburgh.

Broncos vs. Chiefs odds

Opening line

• Chiefs -10.5
• Over/Under 51.5
• View full Broncos vs. Chiefs line movement
• Read our Broncos vs. Chiefs picks and predictions 

The Chiefs opened just above the key number at -10.5 for this AFC West matchup on Thursday Night Football. Denver is coming off a nasty loss to the Jets at home and finds itself in a tough spot, playing its third road game in four weeks on a short week with a trip to Arrowhead. No word on Taylor Swift's status for TNF just yet.

Also see: full Thursday Night Football odds

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Ravens vs. Titans odds

Opening line

• Titans +4
• Over/Under 40.5
• View full Ravens vs. Titans line movement
• Read our Ravens vs. Titans picks and predictions

Neither side looked great in Week 5 losses, and Baltimore opened between -3.5 and -4 in a neutral-site matchup with the Titans. The Ravens run one tough schedule spot in Week 6, not only having to cross the pond and play at 9:30 a.m. ET but this will be the team’s third straight game away from home and fourth travel game in five weeks.

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Commanders vs. Falcons odds

Opening line

• Falcons -2
• Over/Under 42
• View full Commanders vs. Falcons line movement
• Read our Commanders vs. Falcons picks and predictions 

The Falcons squeaked out a Week 5 win at home and stay in Atlanta for their fourth home stand in six weeks when Washington comes to visit. The Commanders were embarrassed by the Bears on Thursday Night Football and have allowed scores of 40, 31, 37, and 33 in regulation the past four games. Atlanta opened as a 2-point home favorite and up to -2.5 at some online markets.

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Vikings vs. Bears odds

Opening line

• Bears +3.5
• Over/Under 49.5
• View full Vikings vs. Bears line movement
• Read our Vikings vs. Bears picks and predictions

The Vikings lost a hard-fought home stand against Kansas City and perhaps lost star WR Justin Jefferson to a hamstring injury, which has knocked this spread down from Minnesota -4.5 on the look-ahead line to an opener of -3.5. Chicago gets a mini bye after blasting Washington on Thursday. This total opened at 49.5 points but is down to 48.5 at some shops on Sunday night.

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Seahawks vs. Bengals odds

Opening line

• Bengals -2.5
• Over/Under 45.5
• View full Seahawks vs. Bengals line movement
• Read our Seahawks vs. Bengals picks and predictions

The Bengals snapped out of their offensive funk against Arizona in Week 5 and bring that attack back home to face the Seahawks, who enjoyed a bye in Week 5 after blasting the Giants in their most recent outing. Cincinnati opened as a 2.5-point favorite while the total has jumped from 45.5 to as high as 46.5 points on Sunday night.

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49ers vs. Browns odds

Opening line

• Browns +5
• Over/Under 38.5
• View full 49ers vs. Browns line movement
• Read our 49ers vs. Browns picks and predictions

The 49ers are coming off a perfect performance on Sunday Night Football, a 42-10 beatdown of the Dallas Cowboys. The Browns will turn to P.J. Walker at quarterback if Deshaun Watson is unable to go, which is a scary proposition. Sportsbooks opened the Niners as 5-point road favorites with a total of 38.5.

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Saints vs. Texans odds

Opening line

• Texans +2
• Over/Under 41
• View full Saints vs. Texans line movement
• Read our Saints vs. Texans picks and predictions

The Saints smashed the Patriots 34-0 in Week 5 and stay on the road when they visit Houston. The Texans lost a tight one against Atlanta and opened as 2-point home pups, with that spread jumping to +2.5 on Sunday night. This is a nasty schedule spot for NOLA, playing back-to-back road games and four roadies in five weeks, all of which are stuffed into a 27-day window.

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Colts vs. Jaguars odds

Opening line

• Jaguars -5.5
• Over/Under 45.5
• View full Colts vs. Jaguars line movement
• Read our Colts vs. Jaguars picks and predictions

Indianapolis rookie QB Anthony Richardson left Week 5 with a sprained shoulder, leaving his status for Week 6 up in the air. However, the Colts have a capable backup QB in Gardiner Minshew, so the impact to the odds may not to that great. Jacksonville doesn’t get a bye after two weeks in London and opened as a 5.5-point home chalk in this divisional matchup. Early money took Indy and moved this spread to Jacksonville -4.5 on Sunday night.

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Panthers vs. Dolphins odds

Opening line

• Dolphins -14
• Over/Under 48
• View full Panthers vs. Dolphins line movement
• Read our Panthers vs. Dolphins picks and predictions

The Dolphins took down the Giants as near two-touchdown favorites in Week 5 and face another hefty spread in Week 6, opened as 14-point chalk to Carolina. That has come down a bit to -13.5 at some books on Sunday night but is a notable jump from the look-ahead line of Miami -10.5. The Panthers are playing back-to-back road games and their third in four weeks, so keep an eye on the heat and humidity in South Beach on Sunday. 

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Lions vs. Buccaneers odds

Opening line

• Buccaneers +3
• Over/Under 45
• View full Lions vs. Buccaneers line movement
• Read our Lions vs. Buccaneers picks and predictions

The Lions crushed Carolina at home and now travel to Tampa Bay to battle the well-rested Buccaneers, who are coming off a bye week. Detroit opened as a field goal favorite on the road and that is trending toward a move to -3.5, with the juice climbing. The total opened at 45 points.

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Patriots vs. Raiders odds

Opening line

• Raiders -3
• Over/Under 41
• View full Patriots vs. Raiders line movement
• Read our Patriots vs. Raiders picks and predictions

The Raiders scored a big 17-13 win at home on Monday Night Football over the Green Bay Packers, and the Patriots looked awful in a 34-0 loss at home at the hands of the New Orleans Saints. The lookahead line for this matchup was Patriots -1.5, but books opened Monday night at Raiders -3. The total hit betting boards at 41.

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Cardinals vs. Rams odds

Opening line

• Rams -6
• Over/Under 47
• View full Cardinals vs. Rams line movement
• Read our Cardinals vs. Rams picks and predictions 

The L.A. Rams were as low as -4.5 on the look-ahead spread for this NFC West matchup, but with Arizona getting busted by the Bengals and losing RB James Conner in the process (twisted knee - questionable), Los Angeles opened as a 6-point home chalk. This total opened at 46 points and climbed to 47 on Sunday night. 

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Eagles vs. Jets odds

Opening line

• Jets +6.5
• Over/Under 46.5
• View full Eagles vs. Jets line movement
• Read our Eagles vs. Jets picks and predictions

The Jets won an ugly game in Denver, but QB Zach Wilson continued to improve against the worst defense in the NFL. He comes back to reality against the Eagles at home in Week 6. Philadelphia opened as a 6.5-point road chalk with the market leveling out to -6 on Sunday night. The total opened as 46.5 points.

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Giants vs. Bills odds

Opening line

• Bills -13
• Over/Under 46.5
• View full Giants vs. Bills line movement
• Read our Giants vs. Bills picks and predictions

Buffalo was a 12.5-point favorite on the look-ahead line and opened -13 despite losing in London in Week 5. The Giants were just that much worse and QB Daniel Jones left New York’s Week 5 waxing from Miami with a neck injury. His status for Week 6 is up in the air but this market has moved as far as Buffalo -15 in a matter of hours on Sunday night. The Bills did lose another key piece of their defense with LB Matt Milano suffering a broken leg in London.

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Cowboys vs. Chargers odds

Opening line

• Chargers +2
• Over/Under 49.5
• View full Cowboys vs. Chargers line movement
• Read our Cowboys vs. Chargers picks and predictions

The Cowboys lost 42-10 to the San Francisco 49ers on Sunday Night Football, and the Chargers are coming off an extended bye week. Books opened the Cowboys as 2-point road favorites with a total of 49.5.

Also see: full Sunday Night Football odds

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