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The Titans are off to their worst start since beginning 0-5 in 2006, and those Super Bowl aspirations aren't looking so good. Only one team has started 0-4 and reached the playoffs - San Diego in 1992.

Despite the awful start, coach Jeff Fisher is trying to stay positive. His 2002 team started 1-4 but managed to reach the AFC championship game.

"They'll find a way out of this, and that's all we can do," Fisher said. "I know I've said this before, but you come back and you work and you try to find a way to win the next game and keep your focus on improving."

Fisher is sticking with Kerry Collins at quarterback rather than switching to Vince Young even though the 15-year veteran already has almost as many interceptions (six) as he did in all of 2008 (seven).

"Kerry's not the problem," Fisher said of the NFL's 28th-rated passer.

The defense is definitely a problem, and it will have its hands full trying to stop Manning.

The Titans were second in the league in scoring defense a year ago (14.6 ppg) but are tied for 26th this year (27.0). They've struggled to pressure the quarterback and create turnovers, accumulating nine sacks and six interceptions, down from 15 and eight after four games last season.

In last Sunday's 37-17 loss to Jacksonville, Tennessee allowed David Garrard to throw for 323 yards and three touchdowns.

Garrard, a quarterback who directs a run-first offense, picking apart their defense does not bode well for the Titans in this matchup.

Manning has led Indianapolis to a league-best 13 consecutive regular-season wins since last year's loss to the Titans, including a 23-0 home victory over Tennessee in a Week 17 finale with no playoff implications.

The Pro Bowl quarterback threw for 223 yards, two touchdowns and two interceptions at Tennessee last season but could have better luck against a banged-up Titans team that is tied for last in the NFL in pass defense, allowing 282.3 yards per game.

From Tennessee's secondary, nickel back Vincent Fuller is out with a broken right forearm while cornerbacks Cortland Finnegan (hamstring) and Nick Harper (ribs) are listed as day-to-day.

While the Titans defense is in shambles, Indianapolis' is looking strong.

The Colts are tied for fourth in the league in both scoring defense (15.5) and sacks (12) with defensive ends Dwight Freeney and Robert Mathis already recording five sacks each.

Freeney, Mathis and the rest of the Indianapolis defense have completely shut down the run in the last two games, limiting Seattle and Arizona to a combined 73 rushing yards.

"What makes it fun is success," Freeney said. "That's what's going on right now around here. You build off that momentum and everything snowballs."

Plus, the Colts defense could welcome back linebacker Gary Brackett after he missed two games with a sprained knee, and safety Bob Sanders is closer to making his season debut after having his most extensive practice time since undergoing offseason knee surgery.