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Author: [General Discussion] Topic: Study: chemo promotes cancer growth
TheBallDontLie send a private message View Space | Friends | Playbook | My Sportsbook: Pinnacle Sports |
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#1
Posted: 8/6/2012 11:35:17 PM
http://ca.news.yahoo.com/chemotherapy-backfire-boost-cancer-growth-study-164516832.html

No shocker here IMO 
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#2
Posted: 8/6/2012 11:39:33 PM
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#3
Posted: 8/7/2012 12:06:33 AM

It's true, there will never be a cure for cancer because everyone but the victim profits from cancer.
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#4
Posted: 8/7/2012 12:14:42 AM
it's like anti-virus software, keep subscribing to pay your monthly dues to allow mcafee and norton to make new viruses  
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Posted: 8/7/2012 12:53:21 AM
QUOTE Originally Posted by TheCrow:

it's like anti-virus software, keep subscribing to pay your monthly dues to allow mcafee and norton to make new viruses  

well put 
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#6
Posted: 8/7/2012 1:06:11 AM
Everyone should see that Burzynski movie on Netflix just for a sense of the industry
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#7
Posted: 8/7/2012 2:23:09 AM
Golden Goose is absolutely correct. Money talks and people die.
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#8
Posted: 8/7/2012 3:43:38 AM
I hope that drJ would comment on this... I am not sure if his specialty is oncology, but perhaps he could shed some light on the subject...

I have seen people go bezerk over this point of view concerning cancer and the treatment of cancer... 
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Posted: 8/7/2012 4:12:12 AM
Nature Medicine (2012)
    Received 25 April 2011
Accepted 08 June 2012
Published online 05 August 2012

Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B


Senior author of the study Peter S. Nelson, of the Human Biology Division at the Fred Hutchinson Cancer Research Center in Seattle




Nelson told the media:

"Cancer cells inside the body live in a very complex environment or neighborhood. Where the tumor cell resides and who its neighbors are influence its response and resistance to therapy."

The reason chemotherapy eventually fails when treating advanced cancer, said Nelson, is because the dose you would need to give the patient to wipe out the cancer would also kill the patient.

In the lab, you can "cure" almost any cancer: you just give a huge dose of toxic chemotherapy to the cancer cells in the petri dish.

But you can't do that to patients, because the high dose would not only kill cancer cells but also healthy cells, said Nelson..
######################

They studied a type of normal, non-cancerous cell, the fibroblast, that lives near cancer tumors.

In animals, fibroblasts help maintain connective tissue, which is found throughout the body and acts like a "scaffolding" that holds other types of cells and tissue. Fibroblasts are also important for healing wounds and producing collagen.

But under other, non-usual circumstances, they can behave in unexpected ways.

When their DNA is damaged, for instance by chemotherapy, fibroblasts can release a broad range of compounds that stimulate cell growth.

Nelson and colleagues examined cancer cells from prostate, breast and ovarian cancer patients who had been treated with chemotherapy, and found specifically, that when the DNA of fibroblasts near the tumor is damaged by chemotherapy, they start producing a protein called WNT16B in the microenvironment of the tumor.

And, they also found, when the protein reaches a high enough level, it causes cancer cells to grow, invade surrounding tissue, and resist chemotherapy.

"The expression of WNT16B in the prostate tumor microenvironment attenuated the effects of cytotoxic chemotherapy in vivo, promoting tumor cell survival and disease progression", they write.

Researchers already knew, that the WNT family of genes and proteins are important for growth of both normal and cancer cells, but this study now reveals they may also have a role in promoting treatment resistance.

The researchers saw some WNT proteins increased 30-fold, which was "completely unexpected", said Nelson.

Cancer treatments are becoming increasingly specific, using precise "sniper" approaches to target key molecules rather than general "scatter gun" approaches such as damaging DNA.

The researchers say their findings suggest the microenvironment of the tumor can also play a role in the success or failure of these more precise approaches.

For example, the same cancer cell may react quite differently to the same treatment, in different microenvironments.

They suggest their discovery could help make treatments more effective, for instance by finding a way to block the tumor microenvironment's response.


###############################

Professor Fran Balkwill, a Cancer Research UK expert on microenvironments, told the press the study ties in with other studies that show "cancer treatments don't just affect cancer cells, but can also target cells in and around tumors".

Sometimes the effect can be helpful, said Balkwill, giving the example of when chemotherapy triggers health immune cells to attack nearby tumors.

"But this work confirms that healthy cells surrounding the tumor can also help the tumor to become resistant to treatment. The next step is to find ways to target these resistance mechanisms to help make chemotherapy more effective," he added.

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#10
Posted: 8/7/2012 6:54:23 AM
QUOTE Originally Posted by dl36:

I hope that drJ would comment on this... I am not sure if his specialty is oncology, but perhaps he could shed some light on the subject...

I have seen people go bezerk over this point of view concerning cancer and the treatment of cancer... 


+1
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#11
Posted: 8/7/2012 8:24:54 AM
Many drugs and treatments have risks and benefits.  Doctors decide to prescribe them when benefits outweigh risks. 
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#12
Posted: 8/7/2012 8:38:31 AM
Many cancers are preventable by life style modifications.

Some cancers can't be prevented by life style modifications.

Some cancers can be completely cured by Surgery,Chemotherapy or Radiotherapy, or combinations of the three.

Much usage of Chemotherapy is palliative and not curative.

Agree with  thirdperson "Many drugs and treatments have risks and benefits.  Doctors decide to prescribe them when benefits outweigh risks. "


Cytotoxic drugs used in chemotherapy have major side effects, but  the seriousness of the condition that they are prescribed for justifies their use.

And I will add to what thirdperson posted, by saying the use of treatments is by informed consent.
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#13
Posted: 8/7/2012 2:51:56 PM
QUOTE Originally Posted by thirdperson:

Many drugs and treatments have risks and benefits.  Doctors decide to prescribe them when benefits outweigh risks. 



well said...

had a dentist tell me not to take ibprofen... had an MD tell me im young and i could take it on a regular basis....


lol
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#14
Posted: 8/7/2012 4:13:19 PM
QUOTE

Originally Posted by hotdamn85:




well said...

had a dentist tell me not to take ibprofen... had an MD tell me im young and i could take it on a regular basis....


lol

Your MD must have received his degree from the University of Imadumbfuck. Either that or he doesn't give a garbage regarding your gut or kidneys.

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Posted: 8/7/2012 4:50:25 PM
QUOTE Originally Posted by amd:

Your MD must have received his degree from the University of Imadumbfuck. Either that or he doesn't give a garbage regarding your gut or kidneys.



Ibuprofen is the safest NSAID. NSAID'S are necessary to treat many medical conditions.You can't criticize the prescribing of Ibuprofen unless you know the medical condition it was prescribed for and if it is safe for that individual to take it. Even individuals with gastric conditions if they require Ibuprofen, can be given it with a PPI for gastric protection.
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#16
Posted: 8/7/2012 5:05:57 PM
'Tis true..

A cure cannot be found or a massive industry goes away..and the doctors that treat it.
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#17
Posted: 8/7/2012 5:07:40 PM
http://phoenixtears.ca/
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Posted: 8/7/2012 5:37:02 PM
QUOTE Originally Posted by wallstreetcappers:

'Tis true..

A cure cannot be found or a massive industry goes away..and the doctors that treat it.



many cancers can be cured now.

if you could overnight develop treatments to cure every cancer  at any  stage of development, the industry would not go away, doctors would not go away, because people will still get cancer and require treatment. Industry still required to produce the  treatment and doctors and nurses required to treat and manage patients.



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#19
Posted: 8/7/2012 6:06:59 PM
BMA,

A cure is not chemo..that is treating the disease.

What "cure" is there to any cancer that does not involve serious surgery or therapy that itself can cause death?
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#20
Posted: 8/7/2012 6:16:41 PM
QUOTE Originally Posted by wallstreetcappers:

BMA,

A cure is not chemo..that is treating the disease.

What "cure" is there to any cancer that does not involve serious surgery or therapy that itself can cause death?



Hodgkins and Testicular depending on stage and in testicular the histology, chemotherapy can cure alone


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#21
Posted: 8/7/2012 6:21:39 PM
chemotherapy kills people.

I dont consider a "cure" something that itself kills people.


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#22
Posted: 8/7/2012 9:36:38 PM
BMA...I know what NSAIDS are and how they should be prescribed but like anything else, too much Ibuprofen can be harmful on many levels and it was irresponsible for that dumbass "MD" to say he could take ibuprofen on a regular basis just because he was "young." Just because he/she has a MD doesn't mean they should be practicing. I can attest to that based on what I see every friggin day.
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#23
Posted: 8/7/2012 9:37:45 PM
* MD license
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#24
Posted: 8/7/2012 9:46:29 PM
.....And, we no longer prescribe ppi's for prophylaxis as it is now known to contribute to the break down of  our "normal" flora which causes secondary infections such as Clostridium Difficile.
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#25
Posted: 8/7/2012 11:07:44 PM
QUOTE Originally Posted by amd:

.....And, we no longer prescribe ppi's for prophylaxis as it is now known to contribute to the break down of  our "normal" flora which causes secondary infections such as Clostridium Difficile.




Current Therapeutic indications  Lansoprazole

Lansoprazole is effective in the treatment of acid-related disorders of the upper gastro-intestinal tract, with the benefit of rapid symptom relief. Lansoprazole is also effective in combination with antibiotics in the eradication of Helicobacter pylori (H. pylori).

Indications

Healing and long term management of Gastro Oesophageal Reflux Disease (GORD).

Healing and maintenance therapy for patients with duodenal ulcer.

Relief of reflux-like symptoms (e.g. heartburn) and/or ulcer-like symptoms (e.g. upper epigastric pain) associated with acid-related dyspepsia.

Healing of benign gastric ulcer.

Treatment and prophylaxis of NSAID-associated benign gastric ulcers, duodenal ulcers and relief of symptoms in patients requiring continued NSAID treatment.

Long term management of pathological hypersecretory conditions including Zollinger-Ellison syndrome.

Lansoprazole is also effective in patients with benign peptic lesions, including reflux oesophagitis, unresponsive to H2 receptor antagonists.

Eradication of H. pylori from the upper gastrointestinal tract when used in combination with appropriate antibiotics in patients with gastritis or duodenal ulcer leading to the healing and prevention of relapse of the ulcer. 


#################



Without repeating most of the above

##################


For Omeprazole

Treatment of NSAID-associated gastric and duodenal ulcers

• Prevention of NSAID-associated gastric and duodenal ulcers in patients at risk

############################
The Cochrane Library (named after Archie Cochrane) is a collection of databases in medicine and other healthcare specialties provided by the Cochrane Collaboration and other organisations. At its core is the collection of Cochrane Reviews, a database of systematic reviews and meta-analyses which summarize and interpret the results of medical research. The Cochrane Library aims to make the results of well-conducted controlled trials readily available and is a key resource in evidence-based medicine.

"
Medications to prevent NSAID-induced gastroduodenal ulcers

The results of this meta-analysis demonstrate that misoprostol, proton pump inhibitors, and double doses of H2-receptor antagonists are effective at reducing the risk of both gastric and duodenal non steroidal anti-inflammatory (NSAID) medications induced ulcers. In high risk patients, the use of a traditional NSAID + PPI appears equivalent to a COX-2 inhibitor alone. The most effective strategy in high risk GI patients appears to be the combination of a COX-2 inhibitor + PPI."


links

cochrane

cochrane 2

Omeprazole data sheet click @ 4.1 in table of contents for therapeutic indications


Lansoprazole click @ 4.1 again in that drug data sheet



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