Bills 27, Jaguars 20: EJ Manuel passed for two touchdowns and ran for another and Stephon Gilmore intercepted a pass by Chad Henne in the end zone late in the game to preserve a road win for Buffalo.
Manuel finished 17-of-24 for 193 yards with an interception and threw TD passes to Robert Woods and Frank Summers as Buffalo (5-9) won for only the second time in its last seven games. Fred Jackson rushed for 80 yards and C.J. Spiller added 67 as Buffalo rolled up 198 yards on the ground.
Jordan Todman rushed for 109 yards and added 44 on four receptions while starting in place of Maurice Jones-Drew (hamstring) as Jacksonville (4-10) had its three-game winning streak snapped. Chad Henne was 21-of-36 for 237 yards with two touchdowns and two interceptions.
Jacksonville took a 10-3 lead on Henne's 12-yard TD pass to Ace Sanders, but the Jaguars went three-and-out on consecutive series and lost fumbles on their next two possessions - including Denard Robinson's at the 1-yard line that went through the end zone for a touchback. Manuel hit Woods for a 7-yard TD to tie it and added an 8-yard scoring run before Dan Carpenter's 40-yard field goal gave the Bills a 20-10 halftime advantage.
Josh Scobee's 55-yard field goal - matching the second-longest of his career - pulled the Jaguars within a touchdown, and Winston Guy's strip-sack of Manuel set up Henne's 13-yard TD pass to Marcedes Lewis early in the fourth quarter to tie it. After Manuel's 1-yard toss to Summers capped an 80-yard drive to put the Bills back in front, Jacksonville drove to the 1 before Todman was dropped for a 4-yard loss and Gilmore picked off Henne's lob to the back of the end zone.
GAME NOTEBOOK: Manuel has 11 touchdown passes, surpassing Dennis Shaw (10 in 1970) for the franchise record for a rookie. … Lewis has caught a touchdown pass in three straight games for the first time in his career. … Buffalo sacked Henne five times, running its NFL-best total to 49.