Giants 26, 49ers 3: Ahmad Bradshaw ran for 116 yards and a touchdown while Lawrence Tynes kicked four field goals as visiting New York scored 26 unanswered points in the dominant victory.
Victor Cruz hauled in a touchdown pass for the Giants (4-2), who have won five of their last six regular-season meetings with the 49ers, including an overtime victory in last season's NFC Championship game.
After spotting San Francisco (4-2) a 3-0 lead late in the first quarter, New York took the lead for good less than five minutes into the second when Eli Manning hit Cruz over the middle for a 6-yard touchdown. Tynes kicked a 34-yard field goal later in the quarter to increase the advantage to 10-3.
Bradshaw scored on a 1-yard run early in the third and Tynes converted from 30 and 22 yards out before nine minutes had expired in the session for a commanding 23-3 lead. Tynes added a 32-yarder late in the fourth to cap the scoring.
Alex Smith completed 19 of 30 passes for 200 yards but had three interceptions for the 49ers, who outscored their opponents 79-3 over their previous two games.
GAME NOTEBOOK: Smith had not thrown more than one interception in a game since Oct. 10, 2010, against Philadelphia. ... Bradshaw eclipsed the 100-yard rushing mark for the 10th time in his career. He became just the second running back to gain 100 yards against the 49ers in their last 44 games. ... Manning was 15-of-28 for 193 yards, ending his streak of consecutive 200-yard passing games at 24.