Peyton Manning threw for 325 yards and three touchdowns, including two to Austin Collie, as the Indianapolis Colts defeated the Denver Broncos 27-13 on Sunday.

Collie had 12 catches for 171 yards and the two scores for the Colts (2-1), who have won five straight over the Broncos.

Manning’s 23-yard TD pass to Collie with 4:34 left in the fourth quarter gave the Colts a 27-13 lead. The pair also connected for a 5-yard touchdown in the second quarter.

Kyle Orton was 37 of 57 for 476 yards with a touchdown and an interception, Brandon Lloyd caught six passes for 169 yards and a touchdown and Jabar Gaffney had 12 catches for 140 yards for the Broncos (1-2).

Manning found Blair White for a 9-yard touchdown pass to give the Colts a 20-10 lead with 4:57 left in the third quarter. White was signed off the practice squad this week to replace Pierre Garcon, who missed the game with a hamstring injury.

Adam Vinatieri kicked two field goals – 38 and 33 yards – in the first quarter for the Colts.

Broncos running back Knowshon Moreno missed the game with a pulled left hamstring. Moreno missed all four preseason games with a pulled right hamstring.