Athletics 6, Cardinals 1: Bartolo Colon won his eighth consecutive start and Stephen Vogt hit his first career home run as host Oakland cruised in the opener of the three-game interleague series.
Josh Donaldson went 2-for-3 with an RBI and Seth Smith hit a two-run single for the Athletics, who improved to 3-0 on their eight-game homestand.
Colon (11-2) limited St. Louis to one run and six hits while working eight innings for the second straight outing. The 40-year-old right-hander, who walked one and struck out five, eclipsed his win total of last season and reached 11 for the first time since going 21-8 and winning the American League Cy Young Award in 2005 with the Los Angeles Angels.
Oakland jumped on Shelby Miller (8-6) for five runs in the second inning, with Josh Reddick and Jed Lowrie sandwiching RBI doubles around Smith's two-run base hit. Vogt made it 6-0 by leading off the fourth with a blast to right field on an 0-2 pitch from Joe Kelly for his first hit in 33 major-league at-bats and second career RBI.
David Freese went 2-for-3 with an RBI while Matt Holliday and Matt Carpenter also had two hits apiece for the struggling Cardinals, who have lost five of six to fall one game behind Pittsburgh in the National League Central.
GAME NOTEBOOK: Miller surrendered five runs on six hits and two walks while recording only five outs. He has lost three of his last four starts. ... The Athletics have outscored their opponents 18-4 over the first three games of their homestand. ... Cardinals C Yadier Molina went 0-for-4, grounding into a pair of double plays as his NL-leading batting average fell to .352.