Nationals 5, Mets 2: Stephen Strasburg struck out 11 over seven brilliant innings and Michael Morse and Danny Espinosa belted back-to-back homers as visiting Washington completed a three-game sweep of reeling New York.
Adam LaRoche provided insurance in the seventh inning with a two-run shot for the Nationals, who have won five in a row overall and nine of 12 versus New York this season.
The slumping Mets lost all six games on their homestand and 12 of their last 13 overall.
Strasburg (11-4) was the primary reason for Washington's success on Wednesday afternoon. The hard-throwing right-hander became the first pitcher to record 150 strikeouts this season, doing so after notching his 10th of the day.
Strasburg allowed one run on four hits en route to improving to 2-0 in his career versus the Mets.
After Morse led off the second inning by depositing a belt-high fastball from rookie Jeremy Hefner (1-4) into the seats in right field, Espinosa capped a 10-pitch at-bat with a shot into the upper deck in right. The blast extended Espinosa's hitting streak to 11 games.
Ike Davis answered with his team-leading 16th homer just inside the right-field foul pole to lead off the second. Jordany Valdespin's RBI groundout trimmed the Nationals' lead to 5-2 in the eighth, but Drew Storen - the fourth reliever of the inning - induced David Wright to ground out to end the threat.
Tyler Clippard retired the side in order in the ninth inning to secure his 18th save.
GAME NOTEBOOK: New York lost all six games on a homestand for the first time since August 2002. ... Strasburg, who recorded his seventh career double-digit strikeout game Wednesday, scattered two hits and struck out nine in six innings in a 4-0 victory over the Mets on April 11. ... The Nationals will visit Milwaukee on Thursday to begin a four-game series with the Brewers. ... The Mets will open an 11-game road trip Thursday with a four-game set versus Arizona.