INDIANS 4, BLUE JAYS 3: Carlos Santana celebrated his 26th birthday by recording his second career two-homer game and Derek Lowe tossed seven solid innings as host Cleveland salvaged the finale of a three-game series with Toronto.
After leading off the second inning with a shot to center field, Santana jumped on a slider from Joel Carreno (0-1) for a two-run homer in the fifth to give Cleveland a 4-2 advantage.
Jack Hannahan had an RBI single in the second inning for the Indians, who ended a five-game losing skid to the Blue Jays.
Lowe (1-0), who was acquired from Atlanta in the offseason, allowed two runs on five hits before exiting the contest. Joe Smith permitted an RBI single to Adam Lind in the eighth, but Chris Perez worked out of a bases-loaded jam in the ninth to record his first save.
Edwin Encarnacion had an RBI double and Brett Lawrie added a sacrifice fly in the fourth inning for the Blue Jays, who were attempting to begin the season with a 3-0 mark for the first time since 1996.
Making his first major-league start, Carreno yielded four runs on six hits in six innings to take the loss.
GAME NOTEBOOK: Albert Belle was the last member of the Indians to belt two homers on his birthday. He did so in 1995. ... Toronto will host American League East rival Boston for a three-game series starting on Monday. ... Cleveland will continue its six-game homestand against the AL Central rival Chicago White Sox. ... Carreno made 11 appearances out of the bullpen last season.