Twins 6, Yankees 5: Justin Morneau belted a pair of home runs as visiting Minnesota beat New York for the second time in three nights.
Jason Marquis (1-0) overcame a shaky first inning to win his season debut, allowing four runs on seven hits in five innings.
Jamey Carroll and Joe Mauer had RBI doubles in a four-run first and Alexi Casilla had three hits to give Minnesota only its seventh victory in the last 36 regular-season meetings in the Bronx dating to 2002.
Morneau's two-run homer capped the first-inning outburst and his solo shot in the fifth made it 6-4. Morneau has swatted seven homers in 12 games at the new Yankee Stadium - more than his career total at Minnesota's Target Field.
Twins closer Matt Capps surrendered a solo home run to Derek Jeter in the ninth before securing his third save.
Robinson Cano homered and had an RBI double and Nick Swisher added a two-run single for the Yankees, who have lost two home games to the Twins in a series for the first time since 2001.
Yankees starter Hiroki Kuroda (1-2) couldn't build on his stellar Yankee Stadium debut and was rocked for six runs on 10 hits in 4 1/3 innings.
GAME NOTEBOOK: Twins LF Josh Willingham singled in the ninth and has hit safely in all 12 games this season. ... Yankees LF Brett Gardner was scratched from the lineup due to soreness in his right elbow. Yankees manager Joe Girardi said after the game that Gardner will be placed on the 15-day disabled list. Andruw Jones, who homered in Tuesday's win, took his place. ... Yankees lefty reliever Boone Logan struck out four straight batters during his two-inning stint. ... To make room for Marquis on the roster, the Twins cut infielder Luke Hughes on Wednesday. The team must trade, release or send Hughes to the minors within 10 days.