Red Sox 3, White Sox 1: Cody Ross belted a three-run walkoff home run in the ninth inning as host Boston took three of four from Chicago.
After hitting a pair of three-run homers during Wednesday's 10-1 triumph, Ross deposited an inside fastball from closer Addison Reed over the Green Monster for his 16th homer.
The blast spoiled a brilliant performance by rookie Jose Quintana, who scattered five hits over eight sizzling innings. Making his 10th start, Quintana allowed just one hit in his first 6 1/3 innings.
Alfredo Aceves (1-6) picked up the win after allowing two hits in a scoreless ninth inning. Matt Thornton took the loss after yielding singles to two of the three batters he faced in the ninth.
Adrian Gonzalez and Ross had two hits apiece for the Red Sox, who welcomed Dustin Pedroia back to the lineup. The 2008 American League MVP had been sidelined with a strained right thumb and went 1-for-4.
Chicago pushed a run across in the fourth inning after starter Clay Buchholz issued his lone walk of the game to Adam Dunn. Paul Konerko's single advanced Dunn to third base - just ahead of the throw by right fielder Ross. Rios followed with a deep fly to right field, allowing Dunn to cruise home.
Buchholz settled for a no-decision after permitting just six hits and striking out as many in eight innings.
GAME NOTEBOOK: Injured Boston slugger David Ortiz admitted that he plans to take some swings in the cage on Friday. Ortiz, who is on the 15-day disabled list with a strained right Achilles tendon, was wearing a black protective boot on his foot. ... The Red Sox sent right-hander Justin Germano to the Chicago Cubs for cash. ... INF Mauro Gomez was sent to Triple-A Pawtucket to make room for Pedroia. ... Chicago will finish its 10-game road trip by beginning a three-game set with Detroit on Friday. ... Boston will complete its seven-game homestand with a three-game series versus AL East rival Toronto.