New Orleans Saints at Tampa Bay Buccaneers (+3, 48.5)
Drew Brees passed for 357 yards and a pair of touchdowns in Week 1 and torched Tampa Bay for 307 yards and four scores in that Dec. 16 meeting last season. The biggest test for the Saints secondary this week will be against wide receiver Vincent Jackson, who is the best playmaker on Bucs' offense
Tampa Bay was called for five penalties that led to first downs against the Jets, including a personal foul call on linebacker Lavonte David that set up the winning field goal with two seconds left. Freeman completed less than 50 percent of his passes (15-for-31), threw an interception and fumbled the ball out of the back of the end zone for a safety in the contest.
LINE: Saints opened -3.5 and moved to -3. Total moved from 46.5 to 47.
COVERS POWER RANKINGS: Saints (-3.0) + Bucs (+4.0) + home field (-3.0) = Bucs +4
WEATHER: Temps in low 90s. 30 percent chance of thundershowers. Winds east 6 mph.
* Under is 8-1 in the last nine meetings.
* Saints are 7-3 ATS in their last 10 meetings.
* Road team is 14-6 ATS in their last 20 meetings.
Detroit Lions at Arizona Cardinals (+1, 47.5)
Detroit came out of Week 1 healthy but is likely another week away from getting receiver Ryan Broyles back from a knee injury. The Lions can survive without Broyles thanks to a bevy of offensive weapons including Calvin Johnson and Reggie Bush, who had 90 rushing yards and 101 receiving yards in his Detroit debut.
New starting quarterback Carson Palmer had a solid outing in Week 1, passing for 327 yards and two touchdowns, but he also threw an interception and was sacked four times. The Cardinals might be without two major offensive weapons as receiver Larry Fitzgerald and running back Rashard Mendenhall both are questionable with hamstring injuries.
LINE: Game opened pick and moved to Detroit -1. Total moved from 46.5 to 48.5.
COVERS POWER RANKINGS: Lions (0.0) + Cardinals (+5.0) + home field (-3.0) = Cardinals +2
* Home team is 9-0 ATS in their last nine meetings.
* Over is 8-1 in the last nine meetings.
* Favorite is 6-2 ATS in their last eight meetings.
Jacksonville Jaguars at Oakland Raiders (-4, 40.5)
The Jacksonville Jaguars will be without quarterback Blaine Gabbert when they visit the Oakland Raiders on Sunday. The second-year quarterback suffered a nasty laceration on his throwing hand that required 15 stitches during a season-opening 28-2 loss to the Kansas City Chiefs and veteran Chad Henne will start against the Raiders.
Oakland QB Terrelle Pryor was just the eighth quarterback since the 1970 merger to pass for at least 200 yards and run for 100 in the same game. Getting Darren McFadden untracked is crucial after the sixth-year back had only 48 yards – and a paltry 2.8 average – against the Colts. McFadden was limited to 53 yards (and a 2.8 average) by the Jaguars last season. Oakland recorded four sacks in the opener, a welcome development after having just 25 last season.
LINE: Oakland opened -7 and has moved to -5.5. Total moved from 39.5 to 39.
COVERS POWER RANKINGS: Jaguars (+7.5) - Raiders (+7.0) + home field (-3.0) = Raiders -3.5
WEATHER: Temps in mid 70s with clear skies. Winds WSW 12 mph.
* Jaguars are 5-0 ATS in their last five meetings.
* Raiders are 1-5 ATS in their last six home games.
* Under is 4-0 in Raiders' last four home games.
Denver Broncos at New York Giants (+3.5, 53.5)
Denver QB Peyton Manning won the previous two matchups SU and ATS versus his brother Eli when he was a member of the Indianapolis Colts. The Broncos run game remains in flux but the defense had four sacks and two interceptions despite the absences of Pro Bowlers Von Miller (suspension) and Champ Bailey (foot).
New York has serious concerns about its running game after starter David Wilson lost two fumbles and was benched and backup Da'Rel Scott was injured, necessitating the signing of former Giants back Brandon Jacobs. New York's receiving corps showed it has the requisite firepower to keep up with the Broncos, getting three touchdown receptions from Victor Cruz. The Giants could be shorthanded in the defensive backfield after cornerback Prince Amukamara suffered a concussion versus Dallas.
LINE: Denver opened -2 and moved to -4.5. Total moved from 53.5 to 55.
COVERS POWER RANKINGS: Broncos (-8.0) - Giants (-2.5) + home field (-3.0) = Giants +2.5
WEATHER: Temps in low 70s. Partly cloudy skies. Winds WSW 6 mph.
* Broncos are 5-1 ATS in their last six road games.
* Giants are 9-4 ATS in their last 13 games in Week 2.
* Under is 17-7 in Giants' last 24 games overall.
San Francisco 49ers at Seattle Seahawks (-3, 44)
San Francisco's Colin Kaepernick was sensational in Week 1, throwing for a career-best 412 yards and three touchdowns against an overwhelmed Packers defense. The 49ers were the only NFC West team with a winning road record last season (5-3). San Francisco WR Anquan Boldin, who erupted for 208 receiving yards and a touchdown in his 49ers debut.
When it comes to home-field advantage, no team enjoyed a bigger one last season than the Seahawks. They finished 8-0 at CenturyLink in 2012 and were especially dominant in their final four home games of the campaign, outscoring opponents by a 148-33 margin over that stretch. The home effect was evident when San Francisco visited last season, as the noisy crowd forced Kaepernick to call two first-quarter timeouts.
LINE: Seattle opened -2.5 and moved to -3. Total moved from 44.5 to 44.
COVERS POWER RANKINGS: 49ers (-8.0) - Seahawks (-8.0) + home field (-3.0) = Seahawks -3
WEATHER: Temps in high 60s. 43 percent chance of showers. Winds SW 11 mph.
* Favorite is 4-1 ATS in their last five meetings.
* Home team is 6-2 ATS in their last eight meetings.
* Seahawks are 41-20-2 ATS in their last 63 home games.