Check out our college football Top 25 cheat sheet for Saturday's afternoon action.
Oregon Ducks at Colorado Buffaloes (+38.5, 69)
De'Anthony Thomas, the speedy Ducks junior running back who has six touchdowns while averaging eight yards per carry, is doubtful with an ankle injury. The junior was hurt on the opening kickoff of last week's 55-16 victory over California and did not return, and with No. 18 Washington up next, it would seem Oregon - a 38-point favorite - will not rush him back.
Colorado struggled to contain Oregon State's relentless passing attack in a 44-17 loss last week and is expected to have an even harder time dealing with Ducks dual-threat quarterback Marcus Mariota. The Buffaloes may have found a way to improve on their 103rd-ranked rushing attack as freshman Michael Adkins II rushed for 98 yards against Oregon State in his collegiate debut.
LINE: The Ducks opened -38 and are now -38.5. The total opened at 70 and is down to 69.
WEATHER: Temperatures will be in the high-40s with clear skies.
* Ducks are 10-1 ATS in their last 11 road games.
* Buffaloes are 7-18 ATS in their last 25 games overall.
* Over is 35-17 in Ducks last 52 games overall.
Arkansas Razorbacks at Florida Gators (-11.5, 43)
Arkansas has never had much success against Florida losing eight of their nine previous matchups. Their last game was in 2009 when then-No. 1 Florida needed a field goal with nine seconds left to pull out a 23-20 win. The Razorbacks have dropped two straight after a soft opening schedule, and their powerful rushing game will get a stern test from Florida's top-ranked run defense.
The Gators enter the contest ranked second in the nation total defense but could be without star lineman Dominique Easley and cornerback Marcus Roberson, both of whom are battling knee injuries. Replacing Jeff Driskel, who broke his leg, QB Tyler Murphy completed his first 13 passes last week and finished 15-for-18 for 156 yards.
LINE: The Gators opened at -10 and are currently -11.5. The total opened at 43.
WEATHER: There is a 17 percent chance of rain in the forecast and wind will blow across the field at 6 mph.
* Razorbacks are 1-10 ATS in their last 11 road games.
* Razorbacks are 1-4 ATS in their last five meetings in Florida.
* Favorite is 6-2 ATS in their last eight meetings.
TCU Horned Frogs at Oklahoma Sooners (-10, 46.5)
The TCU defense has piled up a Big 12-leading 15 sacks and has allowed 59 total rushing yards over the past two games. Sophomore quarterback Trevone Boykin has passed for 625 yards and four touchdowns and has 158 yards on the ground.
The Sooners are allowing 12 points per game – sixth-best nationally – and sophomore middle linebacker Frank Shannon (team-best 27 tackles) and Corey Nelson (21) are leading the charge. Oklahoma leads the series 8-4, including a 24-17 road victory last season.
LINE: Oklahoma opened as a 10.5-point fave and is now -10. The total is 46.5.
WEATHER: Temperatures will be in the high-50s with clear skies.
* Horned Frogs are 1-5 ATS in their last six games overall.
* Sooners are 1-4 ATS in their last five conference games.
* Over is 7-2 in Sooners last nine conference games.
LSU Tigers at Mississippi State Bulldgos (+9.5, 55.5)
The Tigers have recorded more than 400 yards of total offense and scored 30 or more points in each of their first five games for the first time in school history. However, Les Miles’ biggest concern entering this contest has to revolve around a defense that blew a number of coverages due to communication errors on the field and the sideline in the loss to Georgia.
The Bulldogs responded in emphatic fashion to their loss at Auburn on Sept. 14, using a 35-point second quarter to rout Troy 62-7. Mississippi State has outscored its two opponents at home (Alcorn State and Troy) by an 82-7 margin in the first half, including a 58-0 advantage in the second quarter.
LINE: LSU opened as a 10-point road dog and is now -9.5. The total opened at 54.5.
WEATHER: There is a 55 percent chance of rain in the forecast.
* Tigers are 4-0 ATS in their last four games following a bye week.
* Over is 5-0 in Tigers last five games overall.
* Tigers are 8-1 ATS in their last nine meetings in Mississippi State.
Arizona State Sun Devils vs. Notre Dame Fighting Irish (+5.5, 62)
Junior quarterback Taylor Kelly has thrown for more than 300 yards in each of the Sun Devils’ first four games, and junior college transfer Jaelen Strong has made an immediate impact with 433 receiving yards and two touchdowns.
The Fighting Irish defense hasn’t been as impressive as last season, but linemen Stephon Tuitt and Louis Nix remain among the best in the country. Linebacker Jarrett Grace has a team-high 37 tackles for Notre Dame, which could struggle to slow down an Arizona State team averaging 44.3 points per game.
LINE: The Irish opened as 5.5-point home dogs. The total opened at 62.
* Fighting Irish are 0-5-1 ATS in their last six games overall.
* Over is 5-1 in Sun Devils last six non-conference games.
* Under is 8-2 in Fighting Irish last 10 games following a ATS loss.
Kentucky Wildcats at South Carolina Gamecocks (-21, 54)
Kentucky faces its third straight nationally ranked foe after losses to Louisville and Florida. The Wildcats have been juggling quarterback duties between Maxwell Smith and Jalen Whitlow, with both showing varying degrees of effectiveness. Kentucky coach Mark Stoops would like to go with one signal caller, but is not in a rush to make that call.
South Carolina has only one home game in October, so the No. 12 Gamecocks know they need to get a win over visiting Kentucky on Saturday to make their hopes for a Southeastern Conference Eastern Division crown easier. The Gamecocks struggled a bit against Central Florida last week, thanks in part to a shoulder injury to starting quarterback Connor Shaw, who may be back against the Wildcats.
LINE: The Gamecocks opened as 21-point home faves. The total opened at 55 and is down to 54.
WEATHER: Temperatures will be in the low-80s with clear skies.
* Wildcats are 0-4 ATS in their last four conference games.
* Over is 6-0 in the last six meetings in South Carolina.
* Favorite is 6-2 ATS in their last eight meetings.
West Virginia Mountaineers at Baylor Bears (-28, 69)
West Virginia stumbled out of the gate this season, but turned heads last week when it upset then-No. 11 Oklahoma State at home. Making his first start, Florida State transfer quarterback Clint Trickett threw for 309 yards as the Mountaineers rebounded from an ugly 37-0 loss at Maryland the week before. Trickett, however, injured his shoulder late in the game and is questionable for Saturday.
Baylor averages a gaudy 751.3 yards of offense and 69.7 points, but has played the likes of Wofford, Louisiana-Monroe and Buffalo. The Bears' defense is has allowed just 23 points thus far.
LINE: The Bears opened at -27 and are currently -28. The total opened at 68.5 and is now 69.
WEATHER: Temperatures will be in the low-70s and wind will blow across the field at 11 mph.
* Under is 8-0 in Mountaineers last eight games overall.
* Over is 20-5-1 in Bears last 26 conference games.
* Bears are 15-2 ATS in their last 17 home games.
Ohio State Buckeyes at Northwestern Wildcats (+7, 61)
No. 3 Ohio State attempts to remain undefeated under second-year coach Urban Meyer and stretch the nation’s longest winning streak to 18 games. Ohio State leads the series 59-14-1 and has won the last four meetings.
The two-quarterback system of senior Kain Colter (237 rushing yards, 77.1 percent completion percentage) and junior Trevor Siemian (67.1 completion percentage for 671 yards and four touchdowns) is clicking as the Wildcats are averaging 41.3 points per game.
LINE: The Buckeyes opened as 5.5-point road faves and are now -7. The total opened at 59 and is up to 61.
WEATHER: There is a 56 percent chance of thunderstorms. Wind will blow toward the north endzone at 13 mph.
* Wildcats are 6-0 ATS in their last six conference games.
* Buckeyes are 4-0 ATS in their last four meetings.
* Over is 4-1 in the last five meetings.
Washington Huskies at Stanford Cardinal (-7.5, 52)
Huskies RB Bishop Sankey ranks first in the nation with 151.8 rushing yards per game and senior quarterback Keith Price ranks 12th in pass efficiency for the Huskies, who haven't trailed all season.
Stanford’s stellar offensive line has helped the Cardinal out rush their last two opponents – Washington State and Arizona State – by a 478-101 margin. The defense is led by linebacker Shayne Skov and linebacker Trent Murphy, who returned an interception for a touchdown last week against the Cougars.
LINE: Stanford opened as a 6.5-point fave and is now -7.5. The total opened at 52.5 and is down to 52.
WEATHER: Temperatures will be in the mid-70s with clear skies.
* Huskies are 1-7 ATS in their last eight road games vs. a team with a winning home record.
* Under is 7-2 in the last nine meetings.
* Huskies are 1-4 ATS in their last five meetings.