Needless to say, Monday's match is a big one. Even at this early stage of the season. Two of the favorites for the Premier League title square off at the hallowed grounds of Old Trafford.
Manchester United v Chelsea (+150, +240, +200)
Why bet Man United: The Red Devils picked up right where last season's championship winning run ended. United thrashed a quality Swansea City side by a score of 4-1 in Wales. As long as Dutch striker Robin Van Persie is up front, United will be a tough beat. Last season's top scorer bagged a pair of goals to get new boss David Moyes off to a flying start.
Key players out/doubtful: Javier Hernández, Nani, Ashley Young, Darren Fletcher
Why bet Chelsea: Jose Mourinho is always a thorn in the side of United. The Special One only lost two out of 10 matches versus United in his first tenure as boss of Chelsea. In their opener versus Hull a week ago, the Blues looked good throughout, but certainly weren't dominant. Chelsea has defeated United 14 times in the Premier League. No club has had better success versus the Red Devils.
Key players out/doubtful: David Luiz, Juan Mata
2012-13 fixture result: Manchester United 0, Chelsea 1
Key betting note: The two clubs met five times in all competitions in 2012-13. Chelsea won three times, with United winning one.