Where the action is: NFL Week 2's biggest line moves

Manning Bowl III headlines Week 2 of the NFL schedule. Peyton Manning is 2-0 versus his little brother but they last met almost three years ago when the Colts defeated the Giants 38-14 on Sept. 19, 2010.

We talk to oddsmakers about the flow of action coming in on some of Sunday's NFL games.

Carolina Panthers at Buffalo Bills - Open: +3

Action on this matchup has sharps and the betting public divided. The Bills are coming off a reasonably strong performance against the Patriots in Week 1, but succumbed to a 23-21 defeat. The Panthers hung around with the Seahawks in a 12-7 loss despite QB Cam Newton not performing at his best.

"Sharp and public money are not seeing eye-to-eye on one of the worst match ups of the weekend," an oddsmaker with BetDSI told Covers. "Sharps are backing Buffalo at +3 (-115) and the the public is all over Carolina at -3 (+100)."

St. Louis Rams at Atlanta Falcons - Open: 47, Move: 47.5, Move: 47

This one has the sharps and public divided as well. The Rams posted a 27-24 Week 1 victory over the Arizona Cardinals while the Falcons were dropped 23-17 by their NFC South rivals the New Orleans Saints.

"There is also a sharp versus public contrast on the St. Louis versus Atlanta match up with public coin backing the Over 47 and sharps coin backing the Under 47.5," an oddsmaker from BetDSI said.

Denver Broncos at New York Giants - Open: +6, Move: +5.5, Move: +4

The third edition of the Manning Bowl is set for Sunday afternoon and sharps are backing Eli as the home dog. The younger Manning finished 27-of-42 for 450 yards in New York's Week 1 loss to the Cowboys.

"Denver opened -6 and Tuesday got sharp play on the dog, so moved to 5.5," Mike Perry of Sportsbook.com told Covers. "Another wiseguy played the Giants +5.5 so moved to current number of 4."

New Orleans Saints at Tampa Bay Buccaneers - Open: +3

One matchup from this weekends schedule which sharps and the public can agree on is the Saints at the Bucs. Drew Brees and the Saints are coming off a big win at home versus the Falcons, and after a particularly dreadful performance against the Jets, nobody is giving the Bucs any love at all.

"Sharps hit the Saints -3 (-105) and the moneyline at -155 and the public is on the Saints too," says BetDSI.com.  "There has been close to zero buy back on Tampa as of yet."

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