The Boston Red Sox head into the 2013 World Series as -145 (Bet365) favorites over the St. Louis Cardinals.
The Sox will play for their first World Series trophy since 2007 when they swept the Colorado Rockies.
The Cardinals, priced at +125, were the 2011 champions after outlasting the Texas Rangers in seven games.
The two clubs did not face one another this season - and haven't since 2008 - but the Sox have the edge in Interleague matchups this season.
Boston posted a 14-6 record against National League opponents and outscored them at a 118-54 clip.
St. Louis was 10-10 against American League teams and had the upper hand in runs as well, outscoring AL opponents 100-75.
It looks as if the series will open with staff aces toeing the rubber at Fenway Park Wednesday evening.
Adam Wainwright is probable to get the call for St. Louis and Jon Lester is the probable starter for the Red Sox.
The Red Sox are Game 1 faves at -125 and the total is currently 7.