Check out our NFL cheat sheet for Week 5's afternoon action.
Carolina Panthers at Arizona Cardinals (+1, 41.5)
After losing its first two games by a total of six points, Carolina turned in a dominant performance against the Giants, rolling up 402 total yards and holding New York to 150. Williams has rushed for 417 yards and two TDs in four meetings with Arizona, including three 100-yard games.
The Arizona defense has been dominant against the run - ranking second in the league - but will have its work cut out against a Panthers team averaging 151 yards on the ground, though unit should be bolstered by the return of linebacker Daryl Washington after he missed the first four games for violating the league's substance abuse policy.
LINE: Opened pick and moved to Arizona +1. Total moved 42 to 41.5.
COVERS POWER RANKINGS: Carolina (+2.0) - Arizona (+4.0) + home field (-3.0) = Cardinals -1
* Road team is 5-2 ATS in their last seven meetings.
* Panthers are 6-2 ATS in their last eight road games.
* Cardinals are 2-5 ATS in their last seven home games.
Denver Broncos at Dallas Cowboys (+7.5, 56)
Denver is putting up 44.8 points and nearly 500 yards of offense. That offense is masking some potential issues on the other side of the ball, where the Broncos rank in the bottom third of the league in total defense. The Broncos have won 15 consecutive regular-season games, each by seven points or more.
Dallas is down two defensive starters in linebacker Justin Durant (groin) and defensive end George Selvie (concussion), who are uncertain for Sunday’s game. That puts even more pressure on Tony Romo and the offense to put up points. Romo is completing 72.4 percent of his passes with eight touchdowns and one interception but could be missing WR Miles Austin (hamstring) questionable.
LINE: Opened Denver -7 and moved as high as -8.5. Total moved 54 to 56.
COVERS POWER RANKINGS: Denver (-9.5) - Dallas (-2.0) + home field (-3.0) = Broncos -4.5
* Broncos are 4-1 ATS in their last five meetings.
* Over is 4-1 in the last five meetings.
* Cowboys are 3-10 ATS in their last 13 home games.
Houston Texans at San Francisco 49ers (-6, 41.5)
Houston ranks second in the AFC in total offense (410.3 yards per game) and leads the NFL in total defense (254.3) but is minus-4 in turnover margin. The Texans expect linebacker Brian Cushing to clear the concussion protocol on Friday and be eligible to play after leaving last week's game in the third quarter.
Colin Kaepernick has been limited in the ground game but rebounded from a pair of poor passing games to throw two touchdown passes against St. Louis. The 49ers lead the NFC in total defense (299.8 yards per game) despite playing without star linebacker Patrick Willis (groin) last week, but they plan to have Willis back Sunday.
LINE: Opened Houston -6.5 and moved to -6. Total moved 42.5 to 41.5.
WEATHER: Mid 60s, clear skies, winds W 6 mph.
COVERS POWER RANKINGS: Houston (-1.5) - San Francisco (-4.0) + home field (-3.0) = 49ers -5.5
* Texans are 0-5 ATS in their last five road games.
* 49ers are 16-7-1 ATS in their last 24 home games.
* Over is 7-1 in 49ers last eight home games.
San Diego Chargers at Oakland Raiders (+4, 45)
San Diego and its already-suspect defense lost linebacker Dwight Freeney for the rest of the season with a torn quadriceps last week. Despite missing WR Malcom Floyd (neck), QB Philip Rivers and the passing game is ranked fifth in the NFL as receiver Eddie Royal (five) and tight end Antonio Gates (two) have already combined for seven receiving touchdowns.
Raiders RB Darren McFadden is questionable with a hamstring injury and RB Marcel Reece is listed as doubtful with a knee injury. Their possible absence will force third-stringer Rashad Jennings into action and put a bigger onus on the unproven shoulders of Pryor, who was fairly impressive throwing for 624 yards and rushing for 198 more in his first three starts of the season.
LINE: Opened Chargers -6 and moved to -4. Total moved 44 to 45.
WEATHER: Mid 60s, clear skies, winds W 2 mph.
COVERS POWER RANKINGS: San Diego (0.0) + Oakland (+6.0) + home field (-3.0) = Chargers -3
* Over is 5-1 in the last six meetings in Oakland.
* Underdog is 8-0 ATS in their last eight meetings.
* Road team is 5-0 ATS in their last five meetings.