Week 1 provided plenty of thrills and surprises - along with the requisite spate of significant injuries. Several teams will head into the second week of action with injury concerns at key positions.
Here is a look at the most important injuries to watch heading into Week 2:
Dez Bryant, WR, and Morris Claiborne, CB, Dallas Cowboys
Bryant, one of the top receivers in football, suffered a mild-foot sprain in the season opener against the New York Giants and may be limited for Sunday's game against the Kansas City Chiefs. The Cowboys will likely limit him in practice to keep him as fresh as possible. Terrance Williams will likely see a significant increase in snaps if Bryant sits or is limited in the game. Owner Jerry Jones says the team will keep an eye on Claiborne, who suffered a dislocated shoulder in the win. Orlando Scandrick or B.W. Webb would likely start in his place.
Early Tuesday odds had the Cowboys as two to 2.5-point underdogs on the road, but it has since risen to three. The O/U is set at 46.5.
Danny Amendola, WR, and Shane Vereen, RB, New England Patriots
The Patriots offense looked uneven in its season-opening victory over Buffalo, and will now be without two more weapons. Amendola suffered a groin injury in Sunday's victory and will be limited all week heading into a likely game-time decision for Thursday's tilt with the New York Jets. Julian Edelman will take Amendola's place in the slot if he can't go. Vereen had a strong opener but suffered a wrist injury that required surgery, knocking him out of action until Week 11 at the earliest. Vereen's injury moves LaGarrette Blount into second spot on the depth chart behind Stevan Ridley.
Despite the losses, New England remains a strong 12-point favorite against the visiting Jets. The O/U stands at 44.
Maurkice Pouncey, C, and Shaun Suisham, K, Pittsburgh Steelers
Pouncey suffered a torn right ACL and MCL in the season opener against Tennessee, effectively ending his season. The Steelers will likely proceed with a combination Fernando Velasco and Kelvin Beachum, a significant downgrade at the position. Suisham suffered a hamstring injury - not that he had much work in the 16-9 loss - and will likely be out until Week 4. The Steelers signed 35-year-old Shayne Graham to take Suisham's place. The Steelers may be hard-pressed to score many TDs against a stout Cincinnati defense, leaving them to turn to Graham's untested foot.
The line has remained steady, with Pittsburgh listed as a seven-point underdog in Ohio. The O/U is set at 40.5.
Blaine Gabbert, QB, Jacksonville Jaguars
Gabbert may have been the luckiest Jaguars player Sunday, leaving early after suffering a hand laceration in a 28-2 drubbing at the hands of the Chiefs. The wound required 15 stitches to close and head coach Gus Bradley says that Gabbert will "definitely" not be on the field for Sunday's game against the Oakland Raiders. Chad Henne will start under center, which may actually mean good things for a Jacksonville offense that sputtered under Gabbert's direction.
The Jaguars opened as 4-point underdogs but the line has since risen to six. The O/U has dropped from 41 to 39.5.
Jacoby Jones, WR, Baltimore Ravens
Quarterback Joe Flacco is running out of viable receiving targets. Jones caught three passes for 24 yards before suffering a sprained MCL against the Denver Broncos Thursday. He'll be sidelined for the next four to six weeks, leaving Flacco with Torrey Smith and rookie Marlon Brown as his top two options. Brown had a strong game in defeat, but struggled at times with separation against the Broncos.
Baltimore enters as a 6.5-point favorite at home to Cleveland. The O/U has also held at 43.5.