If you're looking to bet big but only have a short amount of time to handicap, let our Top-25 cheat sheet help you out. We grabbed some quick-hitting betting info on each of the Top 25 matchups with odds available in Week 3 of the season:
Wake Forest at (6) Florida State (-28.5, 54.5)
Florida State is a 28.5-point favorite in its ACC opener against Wake Forest. The Seminoles' defense has been stout so far, with just three points allowed on a lowly 92 yards per game.
Nebraska's defense was exploited, allowing 653 yards and 36 points to UCLA last week. Cornhuskers’ coach Bo Pelini says running back Rex Burkhead's status against Arkansas State remains uncertain and he’s still considered day-to-day with a knee injury.
(13) Virginia Tech at Pittsburgh (10, 43)
The Hokies hit the road for the first time this season against the Panthers. Virginia Tech holds a 7-4 lead all-time in the series that dates back to 1993. Pitt looks to avoid its first 0-3 start since 2005.
The Horned Frogs will make their Big 12 Conference debut Saturday on the road in Kansas. TCU has won nine straight dating back to last season and is 17-2 in its last 19 road games. The Horned Frogs hold a 16-8-4 edge in the all-time series.
Tennessee Tech at (4) Oregon (TBD)
The Ducks will play their third straight home game to open the season on Saturday against one of the FCS’s most impressive teams thus far, Tennessee Tech. The Golden Eagles are 2-0 for the first time since 1989. Oregon is the only FBS school they face on their schedule.
Furman at (11) Clemson (TBD)
Star wideout Sammy Watkins will make his season debut for the Tigers after serving a two-game suspension as punishment for his legal troubles back in May. This game probably seems insignificant to most bettors but Furman is actually Clemson’s oldest rival. The Tigers holding a 41-10-4 all-time advantage over the Paladins.
North Carolina at (20) Louisville (-3, 52.5)
North Carolina suffered without lead rusher Giovani Bernard (knee) last week and it’s unclear if he will be available against Louisville. The road team is 4-1 ATS in the last five meetings.
Massachusetts at (18) Michigan (-46.5, 57.5)
UMass has been outscored 82-6 against Connecticut and Indiana in its first two games of its inaugural season at the highest level of college football. The over is 8-1 in the Wolverines’ last nine home games vs. a team with a losing road record.
(1) Alabama at (21) Arkansas (21, 53)
Brandon Allen has been taking first-team reps and could be the starting QB for Arkansas on after senior Tyler Wilson suffered a blow to the head in the first half of a stunning loss to Louisiana-Monroe last week. This line opened at -15 and quickly rose above 20 points. Alabama is 5-1 ATS in its last six road games.
(8) West Virginia at James Madison (TBD)
The Dukes have outscored their opponents by a combined 97-10 in the FCS, but will face a top FBS foe on Saturday. West Virginia has won 12 straight against FCS programs.
(17) Florida at Tennessee (-3, 47)
The Volunteers are seeking their first win in eight years over Florida on Saturday night. The Gators have won three straight over the Vols in Knoxville and the road team is 3-0-1 ATS in their last four meetings.
North Texas at (14) Kansas State
Kansas State QB Collin Klein was named the Big 12 Offensive Player of the Week after accounting for four touchdowns in a dominant victory over Miami last week. The Wildcats have won 10 straight contests in September.
UAB at (9) South Carolina (-33.5, 55)
South Carolina coach Steve Spurrier is 45-0 in his college career against teams from outside the BCS. It’s hard to believe he won’t pick up the 200th win of his college coaching career against the Blazers on Saturday.
Florida Atlantic at (7) Georgia (-42, 53.5)
Georgia has put up more than 40 points in each of its first two games and is in the midst of a 12-game, regular-season win streak. The over is 4-0 in the Bulldogs’ last four games vs. Sun Belt opponents.
(3) USC at (16) Stanford (7.5, 56.5)
Trojans’ QB Matt Barkley leads the nation with 10 touchdown passes, tossing six last week to power past Syracuse. Stanford has won four of the last five games between the teams, but has never won four straight over Southern Cal in the 107-year rivalry.
Idaho at (2) LSU (-42, 55)
The Tigers can become the first team in NCAA history to win 40 straight non-conference regular season games Saturday. Idaho is averaging just eight points in its first two games, which ranks 119th out of 120 teams in the FBS.
(19) Notre Dame at (10) Michigan State (-6, 42.5)
Notre Dame holds a 46-28-1 series advantage, including 15 of the last 20 meetings at Spartan Stadium. Nine of the last 12 meetings between the teams have been decided by a touchdown or less.
Utah State at (22) Wisconsin (-14, 51)
Utah State is coming off a huge victory over bitter rival Utah and is undefeated after two games for the first time since 1997. Wisconsin has won 17 straight at Camp Randall Stadium and its last home loss to a non-conference opponent was in 2003. However, Wisconsin is coming off a disappointing defeat at Oregon State last week and this week the Badgers fired their offensive line coach.
(12) Texas at Mississippi (10.5, 47.5)
The Rebels have been outscored by an average of 20.1 points in losing all eight meetings against Top 25 foes over the previous two seasons. Texas is 32-1 against unranked non-conference opponents over the past nine years.
Houston at (23) UCLA (-17, 74)
Jim Mora has helped propel UCLA back into the rankings for the first time since early September 2008 after opening the season with victories over Rice and Nebraska. The home squad is 4-0 ATS in the last four meetings.
South Carolina State at (25) Arizona (TBD)
Quarterback Matt Scott has the Arizona offense firing on all cylinders. The Wildcats are averaging 562.5 yards per game with Scott looking like an All-American in the process. The Arizona defense has to find a way to stop a SCSU rushing attack that is averaging 177.5 yards per game.